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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

Receptor-mediated transcytosis (RMT) is used to enhance the delivery of monoclonal antibodies (mAb) into the central nervous system (CNS). While the binding to endogenous receptors on the brain capillary endothelial cells (BCECs) may facilitate the uptake of mAbs in the brain, a strong affinity for...

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Detalles Bibliográficos
Autores principales:	Chang, Hsueh-Yuan, Wu, Shengjia, Li, Yingyi, Zhang, Wanying, Burrell, Matthew, Webster, Carl I., Shah, Dhaval K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849817/ https://www.ncbi.nlm.nih.gov/pubmed/33499723 http://dx.doi.org/10.1080/19420862.2021.1874121

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