Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

The hematopoietic system is highly sensitive to perturbations in the translational machinery, of which an emerging level of regulation lies in the epitranscriptomic modification of transfer RNAs (tRNAs). Here, we interrogate the role of tRNA anticodon modifications in hematopoiesis by using mouse mo...

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Detalles Bibliográficos
Autores principales: Rosu, Adeline, El Hachem, Najla, Rapino, Francesca, Rouault-Pierre, Kevin, Jorssen, Joseph, Somja, Joan, Ramery, Eve, Thiry, Marc, Nguyen, Laurent, Jacquemyn, Maarten, Daelemans, Dirk, Adams, Christopher M., Bonnet, Dominique, Chariot, Alain, Close, Pierre, Bureau, Fabrice, Desmet, Christophe J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849823/
https://www.ncbi.nlm.nih.gov/pubmed/33507234
http://dx.doi.org/10.1084/jem.20200662

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