5′ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis

Loss-of-function mutations in the ribonuclease angiogenin are associated with amyotrophic lateral sclerosis. Angiogenin has been shown to cleave transfer RNAs during stress to produce ‘transfer-derived stress-induced RNAs’. Stress-induced tRNA cleavage is preserved from single-celled organisms to hu...

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Detalles Bibliográficos
Autores principales: Hogg, Marion C, Rayner, Megan, Susdalzew, Sergej, Monsefi, Naser, Crivello, Martin, Woods, Ina, Resler, Alexa, Blackbourn, Lisle, Fabbrizio, Paola, Trolese, Maria Chiara, Nardo, Giovanni, Bendotti, Caterina, van den Berg, Leonard H, van Es, Michael A, Prehn, Jochen H M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850272/
https://www.ncbi.nlm.nih.gov/pubmed/33543130
http://dx.doi.org/10.1093/braincomms/fcaa138

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