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Acquired Hemophilia A and urothelial carcinoma

Acquired Hemophilia A (AHA) is a rare entity, resulting from the production of autoantibodies against Factor VIII of the coagulation cascade. These autoantibodies may develop in response to autoimmune conditions, drugs, neoplastic diseases, and pregnancy. Diagnosis involves clinical presentation, mu...

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Detalles Bibliográficos
Autores principales: Taza, Fadi, Suleman, Nawar, Paz, Robert, Haas, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850392/
https://www.ncbi.nlm.nih.gov/pubmed/33552425
http://dx.doi.org/10.1080/20009666.2020.1836726
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author Taza, Fadi
Suleman, Nawar
Paz, Robert
Haas, Christopher
author_facet Taza, Fadi
Suleman, Nawar
Paz, Robert
Haas, Christopher
author_sort Taza, Fadi
collection PubMed
description Acquired Hemophilia A (AHA) is a rare entity, resulting from the production of autoantibodies against Factor VIII of the coagulation cascade. These autoantibodies may develop in response to autoimmune conditions, drugs, neoplastic diseases, and pregnancy. Diagnosis involves clinical presentation, mucocutaneous or intramuscular bleeding, and laboratory findings, such as prolonged activated partial thromboplastin time, decreased levels of Factor VIII, and the presence of Factor VIII autoantibodies. The etiology is diverse, with a variety of underlying culprits. Malignancy-associated AHA has been associated with approximately 15% of cases. Urothelial malignancy-mediated AHA is exceedingly rare, with only two previously published reports. The management of AHA includes stabilization and control of bleeding via the use of hemostatic agents, and elimination of the inhibitor with immunosuppressive therapy. Here, we report a case of AHA secondary to urothelial malignancy and review the pathobiology and pathogenesis of Hemophilia A and AHA.
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spelling pubmed-78503922021-02-05 Acquired Hemophilia A and urothelial carcinoma Taza, Fadi Suleman, Nawar Paz, Robert Haas, Christopher J Community Hosp Intern Med Perspect Case Report Acquired Hemophilia A (AHA) is a rare entity, resulting from the production of autoantibodies against Factor VIII of the coagulation cascade. These autoantibodies may develop in response to autoimmune conditions, drugs, neoplastic diseases, and pregnancy. Diagnosis involves clinical presentation, mucocutaneous or intramuscular bleeding, and laboratory findings, such as prolonged activated partial thromboplastin time, decreased levels of Factor VIII, and the presence of Factor VIII autoantibodies. The etiology is diverse, with a variety of underlying culprits. Malignancy-associated AHA has been associated with approximately 15% of cases. Urothelial malignancy-mediated AHA is exceedingly rare, with only two previously published reports. The management of AHA includes stabilization and control of bleeding via the use of hemostatic agents, and elimination of the inhibitor with immunosuppressive therapy. Here, we report a case of AHA secondary to urothelial malignancy and review the pathobiology and pathogenesis of Hemophilia A and AHA. Taylor & Francis 2021-01-26 /pmc/articles/PMC7850392/ /pubmed/33552425 http://dx.doi.org/10.1080/20009666.2020.1836726 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Taza, Fadi
Suleman, Nawar
Paz, Robert
Haas, Christopher
Acquired Hemophilia A and urothelial carcinoma
title Acquired Hemophilia A and urothelial carcinoma
title_full Acquired Hemophilia A and urothelial carcinoma
title_fullStr Acquired Hemophilia A and urothelial carcinoma
title_full_unstemmed Acquired Hemophilia A and urothelial carcinoma
title_short Acquired Hemophilia A and urothelial carcinoma
title_sort acquired hemophilia a and urothelial carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850392/
https://www.ncbi.nlm.nih.gov/pubmed/33552425
http://dx.doi.org/10.1080/20009666.2020.1836726
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