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Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry

This study aimed to evaluate the relationships between different types of antiretroviral therapy (ART) and preterm birth. Preterm birth was studied among all singleton pregnancies and compared between human immunodeficiency virus (HIV)-infected and uninfected women. We performed a matched case-contr...

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Autores principales: Elenga, Narcisse, Djossou, F.é.lix, Nacher, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850744/
https://www.ncbi.nlm.nih.gov/pubmed/33530154
http://dx.doi.org/10.1097/MD.0000000000022670
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author Elenga, Narcisse
Djossou, F.é.lix
Nacher, Mathieu
author_facet Elenga, Narcisse
Djossou, F.é.lix
Nacher, Mathieu
author_sort Elenga, Narcisse
collection PubMed
description This study aimed to evaluate the relationships between different types of antiretroviral therapy (ART) and preterm birth. Preterm birth was studied among all singleton pregnancies and compared between human immunodeficiency virus (HIV)-infected and uninfected women. We performed a matched case-control study from the pregnancy outcome registry of Cayenne Hospital. HIV-infected and uninfected women who delivered in the maternity ward of Cayenne Hospital from January 1, 2013 to December 31, 2015 were studied. We conducted an initial analysis to determine the risk factors for preterm birth among HIV-infected pregnant women. We also evaluated associations between exposure to antiretroviral therapy (ART) and preterm birth. There were 8682 deliveries; of these, 117 involved HIV-infected women, representing a prevalence of 1.34%. There were 470 controls. The sociodemographic characteristics were comparable. HIV-infected women were more likely to experience preterm birth (adjusted odds ratio [AOR] = 3.9, 95% confidence interval [CI] 1.5–9.9). Overall, 95.73% of the women received antiretroviral therapy before becoming pregnant, and they were in good clinical condition. The median CD4 count at the beginning of pregnancy was 500 cells/mm(3) (357–722). Additionally, 53% of HIV-infected women had an undetectable viral load count (<20 copies/mL). Their median haemoglobin level was 120 g/L (100–120). There were 2 human immunodeficiency virus-infected babies. A higher rate of preterm birth was associated with protease inhibitor-based ART than a reverse transcriptase inhibitor-based ART regimen. The sample size being small this result would be considered with caution. The preterm birth rate among HIV-infected pregnant women was twice that of the general population; this trend was not explained by sociodemographic characteristics. Preterm birth was independently associated with combination ART, especially with ritonavir-boosted protease inhibitor therapy during pregnancy.
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spelling pubmed-78507442021-02-02 Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry Elenga, Narcisse Djossou, F.é.lix Nacher, Mathieu Medicine (Baltimore) 6200 This study aimed to evaluate the relationships between different types of antiretroviral therapy (ART) and preterm birth. Preterm birth was studied among all singleton pregnancies and compared between human immunodeficiency virus (HIV)-infected and uninfected women. We performed a matched case-control study from the pregnancy outcome registry of Cayenne Hospital. HIV-infected and uninfected women who delivered in the maternity ward of Cayenne Hospital from January 1, 2013 to December 31, 2015 were studied. We conducted an initial analysis to determine the risk factors for preterm birth among HIV-infected pregnant women. We also evaluated associations between exposure to antiretroviral therapy (ART) and preterm birth. There were 8682 deliveries; of these, 117 involved HIV-infected women, representing a prevalence of 1.34%. There were 470 controls. The sociodemographic characteristics were comparable. HIV-infected women were more likely to experience preterm birth (adjusted odds ratio [AOR] = 3.9, 95% confidence interval [CI] 1.5–9.9). Overall, 95.73% of the women received antiretroviral therapy before becoming pregnant, and they were in good clinical condition. The median CD4 count at the beginning of pregnancy was 500 cells/mm(3) (357–722). Additionally, 53% of HIV-infected women had an undetectable viral load count (<20 copies/mL). Their median haemoglobin level was 120 g/L (100–120). There were 2 human immunodeficiency virus-infected babies. A higher rate of preterm birth was associated with protease inhibitor-based ART than a reverse transcriptase inhibitor-based ART regimen. The sample size being small this result would be considered with caution. The preterm birth rate among HIV-infected pregnant women was twice that of the general population; this trend was not explained by sociodemographic characteristics. Preterm birth was independently associated with combination ART, especially with ritonavir-boosted protease inhibitor therapy during pregnancy. Lippincott Williams & Wilkins 2021-01-29 /pmc/articles/PMC7850744/ /pubmed/33530154 http://dx.doi.org/10.1097/MD.0000000000022670 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 6200
Elenga, Narcisse
Djossou, F.é.lix
Nacher, Mathieu
Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title_full Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title_fullStr Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title_full_unstemmed Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title_short Association between maternal human immunodeficiency virus infection and preterm birth: A matched case-control study from a pregnancy outcome registry
title_sort association between maternal human immunodeficiency virus infection and preterm birth: a matched case-control study from a pregnancy outcome registry
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850744/
https://www.ncbi.nlm.nih.gov/pubmed/33530154
http://dx.doi.org/10.1097/MD.0000000000022670
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