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Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report

RATIONAL: Hemocoagulase, a hemostatic, is used in patients with trauma, gastrointestinal bleeding, or pulmonary hemorrhage or those undergoing surgery. However, paradoxical bleeding after hemocoagulase administration is not considered a clinically significant adverse effect. Here, we report a case o...

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Autores principales: Kim, Tae-Ok, Kim, Min-Suk, Kho, Bo Gun, Park, Ha Young, Kwon, Yong-Soo, Kim, Yu-Il, Lim, Sung-Chul, Shin, Hong-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850761/
https://www.ncbi.nlm.nih.gov/pubmed/33530198
http://dx.doi.org/10.1097/MD.0000000000024040
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author Kim, Tae-Ok
Kim, Min-Suk
Kho, Bo Gun
Park, Ha Young
Kwon, Yong-Soo
Kim, Yu-Il
Lim, Sung-Chul
Shin, Hong-Joon
author_facet Kim, Tae-Ok
Kim, Min-Suk
Kho, Bo Gun
Park, Ha Young
Kwon, Yong-Soo
Kim, Yu-Il
Lim, Sung-Chul
Shin, Hong-Joon
author_sort Kim, Tae-Ok
collection PubMed
description RATIONAL: Hemocoagulase, a hemostatic, is used in patients with trauma, gastrointestinal bleeding, or pulmonary hemorrhage or those undergoing surgery. However, paradoxical bleeding after hemocoagulase administration is not considered a clinically significant adverse effect. Here, we report a case of paradoxical pulmonary hemorrhage associated with hypofibrinogenemia after administration of the hemocoagulase batroxobin in a patient with hemoptysis. PATIENT CONCERNS: An 86-year-old woman complained of hemoptysis during hospitalization with organophosphate poisoning. Hemocoagulase was administered to manage bleeding; however, bleeding signs, such as hemoptysis, massive epistaxis, and ecchymosis, recurred. DIAGNOSES: The patient was diagnosed with acquired hypofibrinogenemia on the basis of the reduced plasma fibrinogen level after hemocoagulase administration and lack of other causes of bleeding. INTERVENTION: Hemocoagulase administration was discontinued, and fibrinogen-containing plasma products were administered. OUTCOMES: The plasma fibrinogen level normalized and bleeding signs did not recur. LESSONS: It is necessary to measure plasma fibrinogen levels regularly in patients undergoing hemocoagulase administration and discontinue its administration when acquired hypofibrinogenemia is detected.
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spelling pubmed-78507612021-02-02 Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report Kim, Tae-Ok Kim, Min-Suk Kho, Bo Gun Park, Ha Young Kwon, Yong-Soo Kim, Yu-Il Lim, Sung-Chul Shin, Hong-Joon Medicine (Baltimore) 6700 RATIONAL: Hemocoagulase, a hemostatic, is used in patients with trauma, gastrointestinal bleeding, or pulmonary hemorrhage or those undergoing surgery. However, paradoxical bleeding after hemocoagulase administration is not considered a clinically significant adverse effect. Here, we report a case of paradoxical pulmonary hemorrhage associated with hypofibrinogenemia after administration of the hemocoagulase batroxobin in a patient with hemoptysis. PATIENT CONCERNS: An 86-year-old woman complained of hemoptysis during hospitalization with organophosphate poisoning. Hemocoagulase was administered to manage bleeding; however, bleeding signs, such as hemoptysis, massive epistaxis, and ecchymosis, recurred. DIAGNOSES: The patient was diagnosed with acquired hypofibrinogenemia on the basis of the reduced plasma fibrinogen level after hemocoagulase administration and lack of other causes of bleeding. INTERVENTION: Hemocoagulase administration was discontinued, and fibrinogen-containing plasma products were administered. OUTCOMES: The plasma fibrinogen level normalized and bleeding signs did not recur. LESSONS: It is necessary to measure plasma fibrinogen levels regularly in patients undergoing hemocoagulase administration and discontinue its administration when acquired hypofibrinogenemia is detected. Lippincott Williams & Wilkins 2021-01-29 /pmc/articles/PMC7850761/ /pubmed/33530198 http://dx.doi.org/10.1097/MD.0000000000024040 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 6700
Kim, Tae-Ok
Kim, Min-Suk
Kho, Bo Gun
Park, Ha Young
Kwon, Yong-Soo
Kim, Yu-Il
Lim, Sung-Chul
Shin, Hong-Joon
Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title_full Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title_fullStr Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title_full_unstemmed Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title_short Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report
title_sort paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: a care-compliant case report
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850761/
https://www.ncbi.nlm.nih.gov/pubmed/33530198
http://dx.doi.org/10.1097/MD.0000000000024040
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