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Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour
This report describes an unusual mesenchymal differentiation in a canine benign mixed mammary tumour. A 13-year-old crossbreed female dog was submitted to surgery to remove an inguinal mammary nodule. The tumour was composed of mammary epithelium and mesenchymal populations, not only of cartilage an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850841/ https://www.ncbi.nlm.nih.gov/pubmed/33564489 http://dx.doi.org/10.1155/2021/6615256 |
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author | Brunetti, Barbara Muscatello, Luisa Vera DeTolla, Louis J. Avallone, Giancarlo |
author_facet | Brunetti, Barbara Muscatello, Luisa Vera DeTolla, Louis J. Avallone, Giancarlo |
author_sort | Brunetti, Barbara |
collection | PubMed |
description | This report describes an unusual mesenchymal differentiation in a canine benign mixed mammary tumour. A 13-year-old crossbreed female dog was submitted to surgery to remove an inguinal mammary nodule. The tumour was composed of mammary epithelium and mesenchymal populations, not only of cartilage and bone but also of myoid cells. PTAH demonstrated cross striation of striated muscle, and immunohistochemistry highlighted striated muscle expressing desmin and calponin, and smooth muscle expressing desmin, SMA, and calponin. The tumour was diagnosed as a benign mixed tumour with leio- and rhabdomyoid differentiation. There was no tumour recurrence after one year of clinical follow-up. In conclusion, the well-differentiated features of leiomyocytes and rhabdomyocytes and the growth pattern define the benign origin of the mesenchymal component, which has been confirmed by a benign outcome; therefore, the knowledge of this kind of differentiation is helpful to avoid misdiagnoses. |
format | Online Article Text |
id | pubmed-7850841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78508412021-02-08 Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour Brunetti, Barbara Muscatello, Luisa Vera DeTolla, Louis J. Avallone, Giancarlo Case Rep Vet Med Case Report This report describes an unusual mesenchymal differentiation in a canine benign mixed mammary tumour. A 13-year-old crossbreed female dog was submitted to surgery to remove an inguinal mammary nodule. The tumour was composed of mammary epithelium and mesenchymal populations, not only of cartilage and bone but also of myoid cells. PTAH demonstrated cross striation of striated muscle, and immunohistochemistry highlighted striated muscle expressing desmin and calponin, and smooth muscle expressing desmin, SMA, and calponin. The tumour was diagnosed as a benign mixed tumour with leio- and rhabdomyoid differentiation. There was no tumour recurrence after one year of clinical follow-up. In conclusion, the well-differentiated features of leiomyocytes and rhabdomyocytes and the growth pattern define the benign origin of the mesenchymal component, which has been confirmed by a benign outcome; therefore, the knowledge of this kind of differentiation is helpful to avoid misdiagnoses. Hindawi 2021-01-23 /pmc/articles/PMC7850841/ /pubmed/33564489 http://dx.doi.org/10.1155/2021/6615256 Text en Copyright © 2021 Barbara Brunetti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Brunetti, Barbara Muscatello, Luisa Vera DeTolla, Louis J. Avallone, Giancarlo Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title | Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title_full | Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title_fullStr | Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title_full_unstemmed | Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title_short | Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour |
title_sort | unusual myoid differentiation in a canine benign mixed mammary tumour |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850841/ https://www.ncbi.nlm.nih.gov/pubmed/33564489 http://dx.doi.org/10.1155/2021/6615256 |
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