Cargando…

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6

Arginine methylation is a post-translational modification that is implicated in multiple biological functions including transcriptional regulation. The expression of protein arginine methyltransferases (PRMT) has been shown to be up-regulated in various cancers. PRMTs have emerged as attractive targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Shuai, Maegawa, Shinji, Yang, Yanwen, Gopalakrishnan, Vidya, Zheng, Guangrong, Cheng, Donghang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850898/ https://www.ncbi.nlm.nih.gov/pubmed/33245113 http://dx.doi.org/10.1042/BCJ20200411

Ejemplares similares

MBRS-64. STUDY OF ARGININE METHYL TRANSFERASES IN MEDULLOBLASTOMA
por: Cheng, Donghang, et al.
Publicado: (2020)

Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1
por: Cao, Meng-Tong, et al.
Publicado: (2023)

The dynamic conformational landscape of the protein methyltransferase SETD8
por: Chen, Shi, et al.
Publicado: (2019)

SETD3 protein is the actin-specific histidine N-methyltransferase
por: Kwiatkowski, Sebastian, et al.
Publicado: (2018)

Cross-Talk Between Histone Methyltransferases and Demethylases Regulate REST Transcription During Neurogenesis
por: Swaminathan, Jyothishmathi, et al.
Publicado: (2022)

Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis
por: Apiz Saab, Juan J, et al.
Publicado: (2023)

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
por: Iannelli, Giulia, et al.
Publicado: (2022)

Protein Arginine Methyltransferase 5 Functions via Interacting Proteins
por: Liang, Zhenzhen, et al.
Publicado: (2021)

Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei
por: Wang, Chongyuan, et al.
Publicado: (2014)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion
por: Allen, William J, et al.
Publicado: (2022)

Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological Evaluation
por: Hu, Hao, et al.
Publicado: (2015)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation
por: Kleinschmidt, Markus A., et al.
Publicado: (2008)

Microbial Transformation of Licochalcones
por: Xiao, Yina, et al.
Publicado: (2019)

Structure, Activity and Function of the Protein Arginine Methyltransferase 6
por: Gupta, Somlee, et al.
Publicado: (2021)

Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs
por: Gayatri, Sitaram, et al.
Publicado: (2016)

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
por: Chen, Xiangrong, et al.
Publicado: (2021)

Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine
por: Byrne, Matthew J., et al.
Publicado: (2020)

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
por: Kong, Gui-Mei, et al.
Publicado: (2017)

Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
por: Al-Hamashi, Ayad A., et al.
Publicado: (2021)

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
por: Iyamu, Iredia D., et al.
Publicado: (2021)

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1
por: Yan, Leilei, et al.
Publicado: (2014)

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
por: Paxman, Ryan, et al.
Publicado: (2018)

Rationally designed peptide-based inhibitor of Aβ(42) fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease
por: Horsley, John R., et al.
Publicado: (2020)

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics
por: Byrne, Dominic P., et al.
Publicado: (2020)

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
por: Vinet, Mathilde, et al.
Publicado: (2019)

Commentary on Urinary l-erythro-β-hydroxyasparagine: a novel serine racemase inhibitor and substrate of the Zn(2+)-dependent d-serine dehydratase
por: Tamaki, Fabio K.
Publicado: (2021)

A commentary on the paper: ‘Evaluation of spice and herb as phytoderived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method’
por: Bilska-Wilkosz, Anna
Publicado: (2022)

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance
por: Spielvogel, Ean, et al.
Publicado: (2023)

Cell Cycle Regulation by the PRMT6 Arginine Methyltransferase through Repression of Cyclin-Dependent Kinase Inhibitors
por: Kleinschmidt, Markus A., et al.
Publicado: (2012)

Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo
por: Zhang, Baolai, et al.
Publicado: (2018)

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors
por: Rathinaswamy, Manoj K, et al.
Publicado: (2021)

Synthetic dosage lethal (SDL) interaction data of Hmt1 arginine methyltransferase
por: Kyriakou, Dimitris, et al.
Publicado: (2020)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression
por: Harrison, Matthew J., et al.
Publicado: (2010)

The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer
por: Lim, Yongchul, et al.
Publicado: (2017)

A DNA aptamer for binding and inhibition of DNA methyltransferase 1
por: Wang, Linlin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ugt0iff27i97ag5iu4tln43b47