DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?

A novel coronavirus disease, COVID-19, has emerged as a global public health issue. Clinical course of disease significantly correlates with the occurrence of some comorbidities, among them type 2 diabetes. According to recent structural studies the dipeptidyl peptidase 4, a key molecule in the path...

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Detalles Bibliográficos
Autores principales: Krejner-Bienias, Alicja, Grzela, Katarzyna, Grzela, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850901/
https://www.ncbi.nlm.nih.gov/pubmed/33527308
http://dx.doi.org/10.1007/s00005-020-00602-5
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author Krejner-Bienias, Alicja
Grzela, Katarzyna
Grzela, Tomasz
author_facet Krejner-Bienias, Alicja
Grzela, Katarzyna
Grzela, Tomasz
author_sort Krejner-Bienias, Alicja
collection PubMed
description A novel coronavirus disease, COVID-19, has emerged as a global public health issue. Clinical course of disease significantly correlates with the occurrence of some comorbidities, among them type 2 diabetes. According to recent structural studies the dipeptidyl peptidase 4, a key molecule in the pathophysiology of diabetes, may influence the course of COVID-19. Since DPP4 inhibitors, gliptins, are widely used in diabetes patients, the exact role of DPP4 modulation in SARS-CoV-2 infection, at least in that group, urgently needs to be clarified. In this short review, we discuss this issue with more detail.
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spelling pubmed-78509012021-02-02 DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End? Krejner-Bienias, Alicja Grzela, Katarzyna Grzela, Tomasz Arch Immunol Ther Exp (Warsz) Review A novel coronavirus disease, COVID-19, has emerged as a global public health issue. Clinical course of disease significantly correlates with the occurrence of some comorbidities, among them type 2 diabetes. According to recent structural studies the dipeptidyl peptidase 4, a key molecule in the pathophysiology of diabetes, may influence the course of COVID-19. Since DPP4 inhibitors, gliptins, are widely used in diabetes patients, the exact role of DPP4 modulation in SARS-CoV-2 infection, at least in that group, urgently needs to be clarified. In this short review, we discuss this issue with more detail. Springer International Publishing 2021-02-02 2021 /pmc/articles/PMC7850901/ /pubmed/33527308 http://dx.doi.org/10.1007/s00005-020-00602-5 Text en © L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Krejner-Bienias, Alicja
Grzela, Katarzyna
Grzela, Tomasz
DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title_full DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title_fullStr DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title_full_unstemmed DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title_short DPP4 Inhibitors and COVID-19–Holy Grail or Another Dead End?
title_sort dpp4 inhibitors and covid-19–holy grail or another dead end?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850901/
https://www.ncbi.nlm.nih.gov/pubmed/33527308
http://dx.doi.org/10.1007/s00005-020-00602-5
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