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Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population
Objective In this currently evolving coronavirus disease 2019 (COVID-19) pandemic, the evidence is scarce about the impact of COVID-19 infection on women in labor and neonates in an inner city African-Americans (AA) population. The objective of this study was to evaluate the clinical outcomes and p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical Publishers, Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850916/ https://www.ncbi.nlm.nih.gov/pubmed/33542856 http://dx.doi.org/10.1055/s-0040-1721673 |
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author | Jani, Sanket Jacques, Suzanne M Qureshi, Faisal Natarajan, Girija Bajaj, Sujit Velumula, Pradeep Agu, Cindy Bajaj, Monika |
author_facet | Jani, Sanket Jacques, Suzanne M Qureshi, Faisal Natarajan, Girija Bajaj, Sujit Velumula, Pradeep Agu, Cindy Bajaj, Monika |
author_sort | Jani, Sanket |
collection | PubMed |
description | Objective In this currently evolving coronavirus disease 2019 (COVID-19) pandemic, the evidence is scarce about the impact of COVID-19 infection on women in labor and neonates in an inner city African-Americans (AA) population. The objective of this study was to evaluate the clinical outcomes and placental pathology in mother–infant dyads in COVID-19 cases. Study Design Retrospective chart review was conducted on 34 COVID-19 positive mother–infant dyads to study their baseline characteristics and outcomes. Placental pathology was reviewed by two perinatal pathologists. Results COVID-19 was noted in 3% of pregnant women who delivered in our institution. The majority (82%) of them were asymptomatic. Out of the four mothers who were symptomatic, only three (9%) required supplemental oxygen. None of them required invasive ventilation. All the neonates tested negative for COVID-19 at 24 hours of age. There were no gross or microscopic pathological abnormalities detected that could be definitely associated with any COVID-19 related complications during pregnancy in any of the 34 placentas. Conclusion COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. Our study did not find any evidence of vertical transmission of COVID-19 infection nor any specific findings on placental pathology. Key Points: Majority of women infected by coronavirus disease 2019 (COVID-19) during labor were asymptomatic. None of the newborns tested positive for COVID-19 at 24 hours of age. Placental pathology findings were nonspecific in COVID-19 mothers. |
format | Online Article Text |
id | pubmed-7850916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Medical Publishers, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78509162021-02-03 Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population Jani, Sanket Jacques, Suzanne M Qureshi, Faisal Natarajan, Girija Bajaj, Sujit Velumula, Pradeep Agu, Cindy Bajaj, Monika AJP Rep Objective In this currently evolving coronavirus disease 2019 (COVID-19) pandemic, the evidence is scarce about the impact of COVID-19 infection on women in labor and neonates in an inner city African-Americans (AA) population. The objective of this study was to evaluate the clinical outcomes and placental pathology in mother–infant dyads in COVID-19 cases. Study Design Retrospective chart review was conducted on 34 COVID-19 positive mother–infant dyads to study their baseline characteristics and outcomes. Placental pathology was reviewed by two perinatal pathologists. Results COVID-19 was noted in 3% of pregnant women who delivered in our institution. The majority (82%) of them were asymptomatic. Out of the four mothers who were symptomatic, only three (9%) required supplemental oxygen. None of them required invasive ventilation. All the neonates tested negative for COVID-19 at 24 hours of age. There were no gross or microscopic pathological abnormalities detected that could be definitely associated with any COVID-19 related complications during pregnancy in any of the 34 placentas. Conclusion COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. Our study did not find any evidence of vertical transmission of COVID-19 infection nor any specific findings on placental pathology. Key Points: Majority of women infected by coronavirus disease 2019 (COVID-19) during labor were asymptomatic. None of the newborns tested positive for COVID-19 at 24 hours of age. Placental pathology findings were nonspecific in COVID-19 mothers. Thieme Medical Publishers, Inc. 2021-01 2021-02-01 /pmc/articles/PMC7850916/ /pubmed/33542856 http://dx.doi.org/10.1055/s-0040-1721673 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Jani, Sanket Jacques, Suzanne M Qureshi, Faisal Natarajan, Girija Bajaj, Sujit Velumula, Pradeep Agu, Cindy Bajaj, Monika Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title | Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title_full | Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title_fullStr | Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title_full_unstemmed | Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title_short | Clinical Characteristics of Mother–Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population |
title_sort | clinical characteristics of mother–infant dyad and placental pathology in covid-19 cases in predominantly african american population |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850916/ https://www.ncbi.nlm.nih.gov/pubmed/33542856 http://dx.doi.org/10.1055/s-0040-1721673 |
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