Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease

Parkinson’s disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary structures, including α-synuclein preformed fibrils (pff). We show that a single system...

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Detalles Bibliográficos
Autores principales: Kuan, Wei-Li, Stott, Katherine, He, Xiaoling, Wood, Tobias C., Yang, Sujeong, Kwok, Jessica C. F., Hall, Katie, Zhao, Yanyan, Tietz, Ole, Aigbirhio, Franklin I., Vernon, Anthony C., Barker, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850975/
https://www.ncbi.nlm.nih.gov/pubmed/31758091
http://dx.doi.org/10.1038/s41380-019-0608-9

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