Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms

Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms....

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Autores principales: Hallikainen, Joona, Keränen, Sara, Savolainen, Jarno, Närhi, Matti, Suominen, Anna Liisa, Ylöstalo, Pekka, Kellokoski, Jari, Pyysalo, Mikko, Pussinen, Pirkko, Rauramaa, Tuomas, Frösen, Juhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850994/
https://www.ncbi.nlm.nih.gov/pubmed/32034564
http://dx.doi.org/10.1007/s10143-020-01253-y
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author Hallikainen, Joona
Keränen, Sara
Savolainen, Jarno
Närhi, Matti
Suominen, Anna Liisa
Ylöstalo, Pekka
Kellokoski, Jari
Pyysalo, Mikko
Pussinen, Pirkko
Rauramaa, Tuomas
Frösen, Juhana
author_facet Hallikainen, Joona
Keränen, Sara
Savolainen, Jarno
Närhi, Matti
Suominen, Anna Liisa
Ylöstalo, Pekka
Kellokoski, Jari
Pyysalo, Mikko
Pussinen, Pirkko
Rauramaa, Tuomas
Frösen, Juhana
author_sort Hallikainen, Joona
collection PubMed
description Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.
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spelling pubmed-78509942021-02-08 Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms Hallikainen, Joona Keränen, Sara Savolainen, Jarno Närhi, Matti Suominen, Anna Liisa Ylöstalo, Pekka Kellokoski, Jari Pyysalo, Mikko Pussinen, Pirkko Rauramaa, Tuomas Frösen, Juhana Neurosurg Rev Review Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence. Springer Berlin Heidelberg 2020-02-07 2021 /pmc/articles/PMC7850994/ /pubmed/32034564 http://dx.doi.org/10.1007/s10143-020-01253-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Hallikainen, Joona
Keränen, Sara
Savolainen, Jarno
Närhi, Matti
Suominen, Anna Liisa
Ylöstalo, Pekka
Kellokoski, Jari
Pyysalo, Mikko
Pussinen, Pirkko
Rauramaa, Tuomas
Frösen, Juhana
Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title_full Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title_fullStr Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title_full_unstemmed Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title_short Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
title_sort role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850994/
https://www.ncbi.nlm.nih.gov/pubmed/32034564
http://dx.doi.org/10.1007/s10143-020-01253-y
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