Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases

We present four cases with Gram-positive bacteremia (pathogens: MRSA n = 1, Enterococcus spp. n = 3) due to an intravascular source (left ventricular assist device: n = 2, transfemoral aortic valve implantation n = 1, prosthetic aortic valve: n = 1) where no curative treatment was available. These p...

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Autores principales: Hitzenbichler, Florian, Mohr, Arno, Camboni, Daniele, Simon, Michaela, Salzberger, Bernd, Hanses, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850995/
https://www.ncbi.nlm.nih.gov/pubmed/32965641
http://dx.doi.org/10.1007/s15010-020-01526-0
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author Hitzenbichler, Florian
Mohr, Arno
Camboni, Daniele
Simon, Michaela
Salzberger, Bernd
Hanses, Frank
author_facet Hitzenbichler, Florian
Mohr, Arno
Camboni, Daniele
Simon, Michaela
Salzberger, Bernd
Hanses, Frank
author_sort Hitzenbichler, Florian
collection PubMed
description We present four cases with Gram-positive bacteremia (pathogens: MRSA n = 1, Enterococcus spp. n = 3) due to an intravascular source (left ventricular assist device: n = 2, transfemoral aortic valve implantation n = 1, prosthetic aortic valve: n = 1) where no curative treatment was available. These patients received indefinite, chronic suppressive (palliative) therapy with dalbavancin (500 mg weekly or 1000 mg biweekly regimens). Outcomes and clinical characteristics are described; treatment was effective in suppression of bacteremia in all patients over several months (range: 1 to more than 12 months), we observed no relevant side effects.
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spelling pubmed-78509952021-02-08 Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases Hitzenbichler, Florian Mohr, Arno Camboni, Daniele Simon, Michaela Salzberger, Bernd Hanses, Frank Infection Case Report We present four cases with Gram-positive bacteremia (pathogens: MRSA n = 1, Enterococcus spp. n = 3) due to an intravascular source (left ventricular assist device: n = 2, transfemoral aortic valve implantation n = 1, prosthetic aortic valve: n = 1) where no curative treatment was available. These patients received indefinite, chronic suppressive (palliative) therapy with dalbavancin (500 mg weekly or 1000 mg biweekly regimens). Outcomes and clinical characteristics are described; treatment was effective in suppression of bacteremia in all patients over several months (range: 1 to more than 12 months), we observed no relevant side effects. Springer Berlin Heidelberg 2020-09-23 2021 /pmc/articles/PMC7850995/ /pubmed/32965641 http://dx.doi.org/10.1007/s15010-020-01526-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Hitzenbichler, Florian
Mohr, Arno
Camboni, Daniele
Simon, Michaela
Salzberger, Bernd
Hanses, Frank
Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title_full Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title_fullStr Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title_full_unstemmed Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title_short Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source—a series of four cases
title_sort dalbavancin as long-term suppressive therapy for patients with gram-positive bacteremia due to an intravascular source—a series of four cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850995/
https://www.ncbi.nlm.nih.gov/pubmed/32965641
http://dx.doi.org/10.1007/s15010-020-01526-0
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