Diagnosis of COVID-19 using multiple antibody assays in two cases with negative PCR results from nasopharyngeal swabs

We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight t...

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Detalles Bibliográficos
Autores principales: Traugott, Marianna Theresia, Hoepler, Wolfgang, Seitz, Tamara, Baumgartner, Sebastian, Karolyi, Mario, Pawelka, Erich, Friese, Emanuela, Neuhold, Stephanie, Kelani, Hasan, Thalhammer, Florian, Zoufaly, Alexander, Laferl, Hermann, Aberle, Judith Helene, Wenisch, Christoph, Puchhammer-Stöckl, Elisabeth, Stiasny, Karin, Aberle, Stephan Walter, Weseslindtner, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851003/
https://www.ncbi.nlm.nih.gov/pubmed/32785885
http://dx.doi.org/10.1007/s15010-020-01497-2
Descripción
Sumario:We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01497-2) contains supplementary material, which is available to authorized users.

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