Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection

A preclinical model of troponin I-induced myocarditis (AM) revealed a prominent role of the immunoproteasome (ip), the main immune cell-resident proteasome isoform, in heart-directed autoimmunity. Viral infection of the heart is a known trigger of cardiac autoimmunity, with the ip enhancing systemic...

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Detalles Bibliográficos
Autores principales: Goetzke, Carl Christoph, Althof, Nadine, Neumaier, Hannah Louise, Heuser, Arndt, Kaya, Ziya, Kespohl, Meike, Klingel, Karin, Beling, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851025/
https://www.ncbi.nlm.nih.gov/pubmed/33523326
http://dx.doi.org/10.1007/s00395-021-00848-w

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