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Total Recall: Intestinal T(RM) Cells in Health and Disease

Tissue-resident memory T cells (T(RM) cells) have crucial functions in host defense in mucosal tissues. They provide local adaptive immune surveillance and allow the fast initiation of targeted adaptive immune responses in case of antigen re-exposure. Recently, an aberrant activation in the case of...

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Autores principales: Paap, Eva-Maria, Müller, Tanja M., Sommer, Katrin, Neurath, Markus F., Zundler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851044/
https://www.ncbi.nlm.nih.gov/pubmed/33542725
http://dx.doi.org/10.3389/fimmu.2020.623072
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author Paap, Eva-Maria
Müller, Tanja M.
Sommer, Katrin
Neurath, Markus F.
Zundler, Sebastian
author_facet Paap, Eva-Maria
Müller, Tanja M.
Sommer, Katrin
Neurath, Markus F.
Zundler, Sebastian
author_sort Paap, Eva-Maria
collection PubMed
description Tissue-resident memory T cells (T(RM) cells) have crucial functions in host defense in mucosal tissues. They provide local adaptive immune surveillance and allow the fast initiation of targeted adaptive immune responses in case of antigen re-exposure. Recently, an aberrant activation in the case of immunologically mediated diseases has been increasingly acknowledged. As the organ with the largest interface to the environment, the gastrointestinal tract faces billions of antigens every day. Tightly balanced processes are necessary to ensure tolerance towards non-hazardous antigens, but to set up a powerful immune response against potentially dangerous ones. In this complex nexus of immune cells and their mediators, T(RM) cells play a central role and have been shown to promote both physiological and pathological events. In this review, we will summarize the current knowledge on the homeostatic functions of T(RM) cells and delineate their implication in infection control in the gut. Moreover, we will outline their commitment in immune dysregulation in gastrointestinal chronic inflammatory conditions and shed light on T(RM) cells as current and potential future therapeutic targets.
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spelling pubmed-78510442021-02-03 Total Recall: Intestinal T(RM) Cells in Health and Disease Paap, Eva-Maria Müller, Tanja M. Sommer, Katrin Neurath, Markus F. Zundler, Sebastian Front Immunol Immunology Tissue-resident memory T cells (T(RM) cells) have crucial functions in host defense in mucosal tissues. They provide local adaptive immune surveillance and allow the fast initiation of targeted adaptive immune responses in case of antigen re-exposure. Recently, an aberrant activation in the case of immunologically mediated diseases has been increasingly acknowledged. As the organ with the largest interface to the environment, the gastrointestinal tract faces billions of antigens every day. Tightly balanced processes are necessary to ensure tolerance towards non-hazardous antigens, but to set up a powerful immune response against potentially dangerous ones. In this complex nexus of immune cells and their mediators, T(RM) cells play a central role and have been shown to promote both physiological and pathological events. In this review, we will summarize the current knowledge on the homeostatic functions of T(RM) cells and delineate their implication in infection control in the gut. Moreover, we will outline their commitment in immune dysregulation in gastrointestinal chronic inflammatory conditions and shed light on T(RM) cells as current and potential future therapeutic targets. Frontiers Media S.A. 2021-01-19 /pmc/articles/PMC7851044/ /pubmed/33542725 http://dx.doi.org/10.3389/fimmu.2020.623072 Text en Copyright © 2021 Paap, Müller, Sommer, Neurath and Zundler http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Paap, Eva-Maria
Müller, Tanja M.
Sommer, Katrin
Neurath, Markus F.
Zundler, Sebastian
Total Recall: Intestinal T(RM) Cells in Health and Disease
title Total Recall: Intestinal T(RM) Cells in Health and Disease
title_full Total Recall: Intestinal T(RM) Cells in Health and Disease
title_fullStr Total Recall: Intestinal T(RM) Cells in Health and Disease
title_full_unstemmed Total Recall: Intestinal T(RM) Cells in Health and Disease
title_short Total Recall: Intestinal T(RM) Cells in Health and Disease
title_sort total recall: intestinal t(rm) cells in health and disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851044/
https://www.ncbi.nlm.nih.gov/pubmed/33542725
http://dx.doi.org/10.3389/fimmu.2020.623072
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