CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs

CD4(+) T cells are crucial for effective repression and elimination of cancer cells. Despite a paucity of CD4(+) T cell receptor (TCR) clinical studies, CD4(+) T cells are primed to become important therapeutics as they help circumvent tumor antigen escape and guide multifactorial immune responses....

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Detalles Bibliográficos
Autores principales: Johnson, Deborah K., Magoffin, Wyatt, Myers, Sheldon J., Finnell, Jordan G., Hancock, John C., Orton, Taylor S., Persaud, Stephen P., Christensen, Kenneth A., Weber, K. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851051/
https://www.ncbi.nlm.nih.gov/pubmed/33542711
http://dx.doi.org/10.3389/fimmu.2020.561889

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