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Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study

The prevalence of mitral valve prolapse (MVP) among middle- and older-aged individuals is estimated to be 2–4% in Western countries. However, few studies have been conducted among Asian individuals and young adults. This study included a sample of 2442 consecutive military adults aged 18–39 years in...

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Autores principales: Liu, Pang-Yen, Tsai, Kun-Zhe, Lin, Yen-Po, Lin, Chin-Sheng, Zeng, Huan-Chang, Takimoto, Eiki, Lin, Gen-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851121/
https://www.ncbi.nlm.nih.gov/pubmed/33526804
http://dx.doi.org/10.1038/s41598-021-81648-z
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author Liu, Pang-Yen
Tsai, Kun-Zhe
Lin, Yen-Po
Lin, Chin-Sheng
Zeng, Huan-Chang
Takimoto, Eiki
Lin, Gen-Min
author_facet Liu, Pang-Yen
Tsai, Kun-Zhe
Lin, Yen-Po
Lin, Chin-Sheng
Zeng, Huan-Chang
Takimoto, Eiki
Lin, Gen-Min
author_sort Liu, Pang-Yen
collection PubMed
description The prevalence of mitral valve prolapse (MVP) among middle- and older-aged individuals is estimated to be 2–4% in Western countries. However, few studies have been conducted among Asian individuals and young adults. This study included a sample of 2442 consecutive military adults aged 18–39 years in Hualien, Taiwan. MVP was defined as displacement of the anterior or posterior leaflet of the mitral valve to the mid portion of the annular hinge point > 2 mm in the parasternal long-axis view of echocardiography. Cardiac chamber size and wall thickness were measured based on the latest criteria of the American Society of Echocardiography. The clinical features of participants with MVP and those without MVP were compared using a two-sample t test, and the cardiac structures were compared using analysis of covariance with adjustment for body surface area (BSA). Eighty-two participants were diagnosed with MVP, and the prevalence was 3.36% in the overall population. Compared with those without MVP, participants with MVP had a lower body mass index (kg/m(2)) (24.89 ± 3.70 vs. 23.91 ± 3.45, p = 0.02) and higher prevalence of somatic symptoms related to exercise (11.0% vs. 4.9%, p = 0.02) and systolic click in auscultation (18.3% vs. 0.6%, p < 0.01). In addition, participants with MVP had greater left ventricular mass (gm) and smaller right ventricular wall thickness (mm) and dimensions (mm) indexed by BSA than those without MVP (149.12 ± 35.76 vs. 155.38 ± 36.26; 4.66 ± 0.63 vs. 4.40 ± 0.68; 26.57 ± 3.99 vs. 25.41 ± 4.35, respectively, all p-values < 0.01). In conclusion, the prevalence and clinical features of MVP in military young adults in Taiwan were in line with those in Western countries. Whether the novel MVP phenotype found in this study has any pathological meaning needs further investigation.
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spelling pubmed-78511212021-02-03 Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study Liu, Pang-Yen Tsai, Kun-Zhe Lin, Yen-Po Lin, Chin-Sheng Zeng, Huan-Chang Takimoto, Eiki Lin, Gen-Min Sci Rep Article The prevalence of mitral valve prolapse (MVP) among middle- and older-aged individuals is estimated to be 2–4% in Western countries. However, few studies have been conducted among Asian individuals and young adults. This study included a sample of 2442 consecutive military adults aged 18–39 years in Hualien, Taiwan. MVP was defined as displacement of the anterior or posterior leaflet of the mitral valve to the mid portion of the annular hinge point > 2 mm in the parasternal long-axis view of echocardiography. Cardiac chamber size and wall thickness were measured based on the latest criteria of the American Society of Echocardiography. The clinical features of participants with MVP and those without MVP were compared using a two-sample t test, and the cardiac structures were compared using analysis of covariance with adjustment for body surface area (BSA). Eighty-two participants were diagnosed with MVP, and the prevalence was 3.36% in the overall population. Compared with those without MVP, participants with MVP had a lower body mass index (kg/m(2)) (24.89 ± 3.70 vs. 23.91 ± 3.45, p = 0.02) and higher prevalence of somatic symptoms related to exercise (11.0% vs. 4.9%, p = 0.02) and systolic click in auscultation (18.3% vs. 0.6%, p < 0.01). In addition, participants with MVP had greater left ventricular mass (gm) and smaller right ventricular wall thickness (mm) and dimensions (mm) indexed by BSA than those without MVP (149.12 ± 35.76 vs. 155.38 ± 36.26; 4.66 ± 0.63 vs. 4.40 ± 0.68; 26.57 ± 3.99 vs. 25.41 ± 4.35, respectively, all p-values < 0.01). In conclusion, the prevalence and clinical features of MVP in military young adults in Taiwan were in line with those in Western countries. Whether the novel MVP phenotype found in this study has any pathological meaning needs further investigation. Nature Publishing Group UK 2021-02-01 /pmc/articles/PMC7851121/ /pubmed/33526804 http://dx.doi.org/10.1038/s41598-021-81648-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Pang-Yen
Tsai, Kun-Zhe
Lin, Yen-Po
Lin, Chin-Sheng
Zeng, Huan-Chang
Takimoto, Eiki
Lin, Gen-Min
Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title_full Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title_fullStr Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title_full_unstemmed Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title_short Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study
title_sort prevalence and characteristics of mitral valve prolapse in military young adults in taiwan of the chief heart study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851121/
https://www.ncbi.nlm.nih.gov/pubmed/33526804
http://dx.doi.org/10.1038/s41598-021-81648-z
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