Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus

Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease sympt...

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Detalles Bibliográficos
Autores principales: Yu, Jieshi, Sreenivasan, Chithra, Uprety, Tirth, Gao, Rongyuan, Huang, Chen, Lee, Ella J., Lawson, Steven, Nelson, Julie, Christopher-Hennings, Jane, Kaushik, Radhey S., Nelson, Eric, Diel, Diego G., Hause, Ben M., Li, Feng, Wang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851141/
https://www.ncbi.nlm.nih.gov/pubmed/33526776
http://dx.doi.org/10.1038/s41541-021-00283-x
Descripción
Sumario:Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.

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