Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus

Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease sympt...

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Autores principales: Yu, Jieshi, Sreenivasan, Chithra, Uprety, Tirth, Gao, Rongyuan, Huang, Chen, Lee, Ella J., Lawson, Steven, Nelson, Julie, Christopher-Hennings, Jane, Kaushik, Radhey S., Nelson, Eric, Diel, Diego G., Hause, Ben M., Li, Feng, Wang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851141/
https://www.ncbi.nlm.nih.gov/pubmed/33526776
http://dx.doi.org/10.1038/s41541-021-00283-x
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author Yu, Jieshi
Sreenivasan, Chithra
Uprety, Tirth
Gao, Rongyuan
Huang, Chen
Lee, Ella J.
Lawson, Steven
Nelson, Julie
Christopher-Hennings, Jane
Kaushik, Radhey S.
Nelson, Eric
Diel, Diego G.
Hause, Ben M.
Li, Feng
Wang, Dan
author_facet Yu, Jieshi
Sreenivasan, Chithra
Uprety, Tirth
Gao, Rongyuan
Huang, Chen
Lee, Ella J.
Lawson, Steven
Nelson, Julie
Christopher-Hennings, Jane
Kaushik, Radhey S.
Nelson, Eric
Diel, Diego G.
Hause, Ben M.
Li, Feng
Wang, Dan
author_sort Yu, Jieshi
collection PubMed
description Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
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spelling pubmed-78511412021-02-08 Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus Yu, Jieshi Sreenivasan, Chithra Uprety, Tirth Gao, Rongyuan Huang, Chen Lee, Ella J. Lawson, Steven Nelson, Julie Christopher-Hennings, Jane Kaushik, Radhey S. Nelson, Eric Diel, Diego G. Hause, Ben M. Li, Feng Wang, Dan NPJ Vaccines Brief Communication Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development. Nature Publishing Group UK 2021-02-01 /pmc/articles/PMC7851141/ /pubmed/33526776 http://dx.doi.org/10.1038/s41541-021-00283-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Yu, Jieshi
Sreenivasan, Chithra
Uprety, Tirth
Gao, Rongyuan
Huang, Chen
Lee, Ella J.
Lawson, Steven
Nelson, Julie
Christopher-Hennings, Jane
Kaushik, Radhey S.
Nelson, Eric
Diel, Diego G.
Hause, Ben M.
Li, Feng
Wang, Dan
Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title_full Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title_fullStr Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title_full_unstemmed Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title_short Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
title_sort piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851141/
https://www.ncbi.nlm.nih.gov/pubmed/33526776
http://dx.doi.org/10.1038/s41541-021-00283-x
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