Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990

Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-se...

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Autores principales: Alfsnes, Kristian, Lagerqvist, Nina, Vene, Sirkka, Bohlin, Jon, Verner-Carlsson, Jenny, Ekqvist, David, Bråve, Andreas, Holmes, Edward C., Shi, Weifeng, Pettersson, John H.-O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851179/
https://www.ncbi.nlm.nih.gov/pubmed/33553563
http://dx.doi.org/10.1016/j.onehlt.2021.100217
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author Alfsnes, Kristian
Lagerqvist, Nina
Vene, Sirkka
Bohlin, Jon
Verner-Carlsson, Jenny
Ekqvist, David
Bråve, Andreas
Holmes, Edward C.
Shi, Weifeng
Pettersson, John H.-O.
author_facet Alfsnes, Kristian
Lagerqvist, Nina
Vene, Sirkka
Bohlin, Jon
Verner-Carlsson, Jenny
Ekqvist, David
Bråve, Andreas
Holmes, Edward C.
Shi, Weifeng
Pettersson, John H.-O.
author_sort Alfsnes, Kristian
collection PubMed
description Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.
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spelling pubmed-78511792021-02-05 Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990 Alfsnes, Kristian Lagerqvist, Nina Vene, Sirkka Bohlin, Jon Verner-Carlsson, Jenny Ekqvist, David Bråve, Andreas Holmes, Edward C. Shi, Weifeng Pettersson, John H.-O. One Health Research Paper Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection. Elsevier 2021-01-22 /pmc/articles/PMC7851179/ /pubmed/33553563 http://dx.doi.org/10.1016/j.onehlt.2021.100217 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Alfsnes, Kristian
Lagerqvist, Nina
Vene, Sirkka
Bohlin, Jon
Verner-Carlsson, Jenny
Ekqvist, David
Bråve, Andreas
Holmes, Edward C.
Shi, Weifeng
Pettersson, John H.-O.
Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title_full Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title_fullStr Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title_full_unstemmed Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title_short Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990
title_sort retrospective meta-transcriptomic identification of severe dengue in a traveller returning from africa to sweden, 1990
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851179/
https://www.ncbi.nlm.nih.gov/pubmed/33553563
http://dx.doi.org/10.1016/j.onehlt.2021.100217
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