Cargando…
Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms for which only symptomatic treatments exist. Exercise is a widely studied complementary treatment option. Aerobic exercise, defined as continuous movement of the body’s large muscles in a rh...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851311/ https://www.ncbi.nlm.nih.gov/pubmed/32808252 http://dx.doi.org/10.1007/s13311-020-00904-8 |
_version_ | 1783645599332040704 |
---|---|
author | Schootemeijer, Sabine van der Kolk, Nicolien M. Bloem, Bastiaan R. de Vries, Nienke M. |
author_facet | Schootemeijer, Sabine van der Kolk, Nicolien M. Bloem, Bastiaan R. de Vries, Nienke M. |
author_sort | Schootemeijer, Sabine |
collection | PubMed |
description | Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms for which only symptomatic treatments exist. Exercise is a widely studied complementary treatment option. Aerobic exercise, defined as continuous movement of the body’s large muscles in a rhythmic manner for a sustained period that increases caloric requirements and aims at maintaining or improving physical fitness, appears promising. We performed both a scoping review and a systematic review on the generic and disease-specific health benefits of aerobic exercise for people with PD. We support this by a meta-analysis on the effects on physical fitness (VO(2)max), motor symptoms (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) motor section), and health-related quality of life (39-item Parkinson’s disease Questionnaire (PDQ-39)). Aerobic exercise has generic health benefits for people with PD, including a reduced incidence of cardiovascular disease, a lower mortality, and an improved bone health. Additionally, there is level 1 evidence that aerobic exercise improves physical fitness (VO(2)max) and attenuates motor symptoms (MDS-UPDRS motor section) in the off-medication state, although the long-term effects (beyond 6 months) remain unclear. Dosing the exercise matters: improvements appear to be greater after training at higher intensities compared with moderate intensities. We found insufficient evidence for a beneficial effect of aerobic exercise on health-related quality of life (PDQ-39) and conflicting results regarding non-motor symptoms. Compliance to exercise regimes is challenging for PD patients but may be improved by adding exergaming elements to the training program. Aerobic exercise seems a safe intervention for people with PD, although care must be taken to avoid falls in at-risk individuals. Further studies are needed to establish the long term of aerobic exercise, including a focus on non-motor symptoms and health-related quality of life. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13311-020-00904-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7851311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-78513112021-02-08 Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease Schootemeijer, Sabine van der Kolk, Nicolien M. Bloem, Bastiaan R. de Vries, Nienke M. Neurotherapeutics Review Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms for which only symptomatic treatments exist. Exercise is a widely studied complementary treatment option. Aerobic exercise, defined as continuous movement of the body’s large muscles in a rhythmic manner for a sustained period that increases caloric requirements and aims at maintaining or improving physical fitness, appears promising. We performed both a scoping review and a systematic review on the generic and disease-specific health benefits of aerobic exercise for people with PD. We support this by a meta-analysis on the effects on physical fitness (VO(2)max), motor symptoms (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) motor section), and health-related quality of life (39-item Parkinson’s disease Questionnaire (PDQ-39)). Aerobic exercise has generic health benefits for people with PD, including a reduced incidence of cardiovascular disease, a lower mortality, and an improved bone health. Additionally, there is level 1 evidence that aerobic exercise improves physical fitness (VO(2)max) and attenuates motor symptoms (MDS-UPDRS motor section) in the off-medication state, although the long-term effects (beyond 6 months) remain unclear. Dosing the exercise matters: improvements appear to be greater after training at higher intensities compared with moderate intensities. We found insufficient evidence for a beneficial effect of aerobic exercise on health-related quality of life (PDQ-39) and conflicting results regarding non-motor symptoms. Compliance to exercise regimes is challenging for PD patients but may be improved by adding exergaming elements to the training program. Aerobic exercise seems a safe intervention for people with PD, although care must be taken to avoid falls in at-risk individuals. Further studies are needed to establish the long term of aerobic exercise, including a focus on non-motor symptoms and health-related quality of life. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13311-020-00904-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-08-17 2020-10 /pmc/articles/PMC7851311/ /pubmed/32808252 http://dx.doi.org/10.1007/s13311-020-00904-8 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Schootemeijer, Sabine van der Kolk, Nicolien M. Bloem, Bastiaan R. de Vries, Nienke M. Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title | Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title_full | Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title_fullStr | Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title_full_unstemmed | Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title_short | Current Perspectives on Aerobic Exercise in People with Parkinson’s Disease |
title_sort | current perspectives on aerobic exercise in people with parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851311/ https://www.ncbi.nlm.nih.gov/pubmed/32808252 http://dx.doi.org/10.1007/s13311-020-00904-8 |
work_keys_str_mv | AT schootemeijersabine currentperspectivesonaerobicexerciseinpeoplewithparkinsonsdisease AT vanderkolknicolienm currentperspectivesonaerobicexerciseinpeoplewithparkinsonsdisease AT bloembastiaanr currentperspectivesonaerobicexerciseinpeoplewithparkinsonsdisease AT devriesnienkem currentperspectivesonaerobicexerciseinpeoplewithparkinsonsdisease |