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Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis

The association between (18)F-fluorodeoxyglucose ((18)F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of (18)F-FDG uptake is a quantitative index of (18)F-FDG metabolism. This study aims to in...

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Autores principales: Nakajo, Masatoyo, Ojima, Satoko, Kawakami, Hirofumi, Tani, Atsushi, Hirayama, Akira, Jinguji, Megumi, Kubozono, Takuro, Ohishi, Mitsuru, Yoshiura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851386/
https://www.ncbi.nlm.nih.gov/pubmed/33526847
http://dx.doi.org/10.1038/s41598-021-82217-0
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author Nakajo, Masatoyo
Ojima, Satoko
Kawakami, Hirofumi
Tani, Atsushi
Hirayama, Akira
Jinguji, Megumi
Kubozono, Takuro
Ohishi, Mitsuru
Yoshiura, Takashi
author_facet Nakajo, Masatoyo
Ojima, Satoko
Kawakami, Hirofumi
Tani, Atsushi
Hirayama, Akira
Jinguji, Megumi
Kubozono, Takuro
Ohishi, Mitsuru
Yoshiura, Takashi
author_sort Nakajo, Masatoyo
collection PubMed
description The association between (18)F-fluorodeoxyglucose ((18)F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of (18)F-FDG uptake is a quantitative index of (18)F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic (18)F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic (18)F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.
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spelling pubmed-78513862021-02-03 Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis Nakajo, Masatoyo Ojima, Satoko Kawakami, Hirofumi Tani, Atsushi Hirayama, Akira Jinguji, Megumi Kubozono, Takuro Ohishi, Mitsuru Yoshiura, Takashi Sci Rep Article The association between (18)F-fluorodeoxyglucose ((18)F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of (18)F-FDG uptake is a quantitative index of (18)F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic (18)F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic (18)F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients. Nature Publishing Group UK 2021-02-01 /pmc/articles/PMC7851386/ /pubmed/33526847 http://dx.doi.org/10.1038/s41598-021-82217-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nakajo, Masatoyo
Ojima, Satoko
Kawakami, Hirofumi
Tani, Atsushi
Hirayama, Akira
Jinguji, Megumi
Kubozono, Takuro
Ohishi, Mitsuru
Yoshiura, Takashi
Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_full Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_fullStr Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_full_unstemmed Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_short Value of Patlak Ki images from (18)F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_sort value of patlak ki images from (18)f-fdg-pet/ct for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851386/
https://www.ncbi.nlm.nih.gov/pubmed/33526847
http://dx.doi.org/10.1038/s41598-021-82217-0
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