Cargando…
Trazodone effects on developing brain
Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholesterol (7-DHC). Recognizing the well-documented, disruptive ef...
Autores principales: | Korade, Zeljka, Allen, Luke B., Anderson, Allison, Tallman, Keri A., Genaro-Mattos, Thiago C., Porter, Ned A., Mirnics, Karoly |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851398/ https://www.ncbi.nlm.nih.gov/pubmed/33526772 http://dx.doi.org/10.1038/s41398-021-01217-w |
Ejemplares similares
-
Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis
por: Korade, Zeljka, et al.
Publicado: (2023) -
Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis
por: Genaro-Mattos, Thiago C., et al.
Publicado: (2020) -
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain
por: Balog, Marta, et al.
Publicado: (2022) -
Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment
por: Genaro-Mattos, Thiago C., et al.
Publicado: (2019) -
Altered Cholesterol Biosynthesis Affects Drug Metabolism
por: Genaro-Mattos, Thiago C., et al.
Publicado: (2021)