Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer

BACKGROUND: To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions work via indirectly activating AMP-activated pro...

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Detalles Bibliográficos
Autores principales: Tailor, Dhanir, Going, Catherine C., Resendez, Angel, Kumar, Vineet, Nambiar, Dhanya K., Li, Yang, Dheeraj, Arpit, LaGory, Edward Lewis, Ghoochani, Ali, Birk, Alisha M., Stoyanova, Tanya, Ye, Jiangbin, Giaccia, Amato J., Le, Quynh-Thu, Singh, Rana P., Sledge, George W., Pitteri, Sharon J., Malhotra, Sanjay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851402/
https://www.ncbi.nlm.nih.gov/pubmed/33139797
http://dx.doi.org/10.1038/s41416-020-01137-4

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