Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevate...

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Detalles Bibliográficos
Autores principales: Yoon, Hyun ah, Riska, Paul F., Jain, Ruchika, Morales, Cariane, Pirofski, Liise-anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851412/
https://www.ncbi.nlm.nih.gov/pubmed/33552883
http://dx.doi.org/10.1016/j.mmcr.2021.01.003
Descripción
Sumario:Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4(+) T cell counts, which likely contributed to greater inflammation.

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