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Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters
Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. All drugs used clinically for killing hypnozoites are 8-am...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851417/ https://www.ncbi.nlm.nih.gov/pubmed/33529838 http://dx.doi.org/10.1016/j.ijpddr.2020.12.004 |
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author | Popovici, Jean Tebben, Kieran Witkowski, Benoit Serre, David |
author_facet | Popovici, Jean Tebben, Kieran Witkowski, Benoit Serre, David |
author_sort | Popovici, Jean |
collection | PubMed |
description | Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. All drugs used clinically for killing hypnozoites are 8-aminoquinolines and among them, primaquine has been at the forefront of P. vivax case management for decades. We discuss here the possible factors that could lead to the emergence and selection of P. vivax primaquine resistant parasites and emphasize on how a better understanding of the mechanisms underlying primaquine treatment and hypnozoite biology is needed to prevent this catastrophic scenario from happening. |
format | Online Article Text |
id | pubmed-7851417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-78514172021-02-05 Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters Popovici, Jean Tebben, Kieran Witkowski, Benoit Serre, David Int J Parasitol Drugs Drug Resist Special issue articles on 'Drug Resistance' Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. All drugs used clinically for killing hypnozoites are 8-aminoquinolines and among them, primaquine has been at the forefront of P. vivax case management for decades. We discuss here the possible factors that could lead to the emergence and selection of P. vivax primaquine resistant parasites and emphasize on how a better understanding of the mechanisms underlying primaquine treatment and hypnozoite biology is needed to prevent this catastrophic scenario from happening. Elsevier 2021-01-24 /pmc/articles/PMC7851417/ /pubmed/33529838 http://dx.doi.org/10.1016/j.ijpddr.2020.12.004 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Special issue articles on 'Drug Resistance' Popovici, Jean Tebben, Kieran Witkowski, Benoit Serre, David Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title | Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title_full | Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title_fullStr | Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title_full_unstemmed | Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title_short | Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters |
title_sort | primaquine for plasmodium vivax radical cure: what we do not know and why it matters |
topic | Special issue articles on 'Drug Resistance' |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851417/ https://www.ncbi.nlm.nih.gov/pubmed/33529838 http://dx.doi.org/10.1016/j.ijpddr.2020.12.004 |
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