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Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA
Discovery of non-coding RNAs has paradigmatically shifted our understanding of the multifaceted nature of cancer. It is becoming progressively more understandable that long non-coding RNAs play fundamental role in regulation of cell signaling pathways in different cancers. DANCR has started to gain...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851422/ https://www.ncbi.nlm.nih.gov/pubmed/33553855 http://dx.doi.org/10.1016/j.ncrna.2021.01.001 |
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author | Farooqi, Ammad Ahmad Mukhanbetzhanovna, Auyezova Ardak Yilmaz, Seher Karasholakova, Lazzat Yulaevna, Ishmuratova Margarita |
author_facet | Farooqi, Ammad Ahmad Mukhanbetzhanovna, Auyezova Ardak Yilmaz, Seher Karasholakova, Lazzat Yulaevna, Ishmuratova Margarita |
author_sort | Farooqi, Ammad Ahmad |
collection | PubMed |
description | Discovery of non-coding RNAs has paradigmatically shifted our understanding of the multifaceted nature of cancer. It is becoming progressively more understandable that long non-coding RNAs play fundamental role in regulation of cell signaling pathways in different cancers. DANCR has started to gain remarkable appreciation because of its central role in cancer onset and progression. In this review we have attempted to summarize emerging aspects of DANCR-mediated regulation of Wnt/β-catenin and JAK/STAT pathways in different cancers. We have also discussed how DANCR epigenetically inactivated tumor suppressors to promote cancer. There is sufficient experimental evidence related to oncogenic role of DANCR in variety of cancers. However, there is a need to uncover how DANCR modulates various other oncogenic pathways in different cancers. |
format | Online Article Text |
id | pubmed-7851422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-78514222021-02-05 Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA Farooqi, Ammad Ahmad Mukhanbetzhanovna, Auyezova Ardak Yilmaz, Seher Karasholakova, Lazzat Yulaevna, Ishmuratova Margarita Noncoding RNA Res Article Discovery of non-coding RNAs has paradigmatically shifted our understanding of the multifaceted nature of cancer. It is becoming progressively more understandable that long non-coding RNAs play fundamental role in regulation of cell signaling pathways in different cancers. DANCR has started to gain remarkable appreciation because of its central role in cancer onset and progression. In this review we have attempted to summarize emerging aspects of DANCR-mediated regulation of Wnt/β-catenin and JAK/STAT pathways in different cancers. We have also discussed how DANCR epigenetically inactivated tumor suppressors to promote cancer. There is sufficient experimental evidence related to oncogenic role of DANCR in variety of cancers. However, there is a need to uncover how DANCR modulates various other oncogenic pathways in different cancers. KeAi Publishing 2021-01-13 /pmc/articles/PMC7851422/ /pubmed/33553855 http://dx.doi.org/10.1016/j.ncrna.2021.01.001 Text en © 2021 [The Author/The Authors] http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Farooqi, Ammad Ahmad Mukhanbetzhanovna, Auyezova Ardak Yilmaz, Seher Karasholakova, Lazzat Yulaevna, Ishmuratova Margarita Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title | Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title_full | Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title_fullStr | Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title_full_unstemmed | Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title_short | Mechanistic role of DANCR in the choreography of signaling pathways in different cancers: Spotlight on regulation of Wnt/β-catenin and JAK/STAT pathways by oncogenic long non-coding RNA |
title_sort | mechanistic role of dancr in the choreography of signaling pathways in different cancers: spotlight on regulation of wnt/β-catenin and jak/stat pathways by oncogenic long non-coding rna |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851422/ https://www.ncbi.nlm.nih.gov/pubmed/33553855 http://dx.doi.org/10.1016/j.ncrna.2021.01.001 |
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