Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome

BACKGROUND: LDL‐cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin‐1 beta (IL‐1β) pathway promotes white adipose tissue (WAT) dysfunction and type 2 di...

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Detalles Bibliográficos
Autores principales: Cyr, Yannick, Lamantia, Valérie, Bissonnette, Simon, Burnette, Melanie, Besse‐Patin, Aurèle, Demers, Annie, Wabitsch, Martin, Chrétien, Michel, Mayer, Gaétan, Estall, Jennifer L., Saleh, Maya, Faraj, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851436/
https://www.ncbi.nlm.nih.gov/pubmed/33527668
http://dx.doi.org/10.14814/phy2.14721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851436/
https://www.ncbi.nlm.nih.gov/pubmed/33527668
http://dx.doi.org/10.14814/phy2.14721

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