Platelet gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific T cells

While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study, ovalbumin (OVA) was used as a surrogate protein. P...

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Detalles Bibliográficos
Autores principales: Li, Jing, Chen, Juan, Schroeder, Jocelyn A., Hu, Jianda, Williams, Calvin B., Shi, Qizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851450/
https://www.ncbi.nlm.nih.gov/pubmed/33575117
http://dx.doi.org/10.1016/j.omtn.2020.12.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851450/
https://www.ncbi.nlm.nih.gov/pubmed/33575117
http://dx.doi.org/10.1016/j.omtn.2020.12.026

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