Cargando…

Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways

Cisplatin is currently used to treat inoperable recurrent meningiomas, but its side effects and drug resistance limit its use. Metformin has recently been identified as a chemosensitizing agent. However, the combined treatment of cisplatin and metformin in high-grade meningiomas has not been reporte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Liemei, Cui, Jing, Wang, Herui, Medina, Rogelio, Zhang, Shilei, Zhang, Xiaohua, Zhuang, Zhengping, Lin, Yingying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851485/ https://www.ncbi.nlm.nih.gov/pubmed/33575476 http://dx.doi.org/10.1016/j.omto.2020.11.004

Ejemplares similares

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells
por: Gao, Chun, et al.
Publicado: (2020)

Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways
por: Zhu, Zhongling, et al.
Publicado: (2021)

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks
por: Sorrenti, Vincenzo, et al.
Publicado: (2022)

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury
por: Wang, Ying, et al.
Publicado: (2020)

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway
por: Li, Shu-xian, et al.
Publicado: (2021)

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
por: Yang, Fan, et al.
Publicado: (2019)

Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression
por: Liao, Keman, et al.
Publicado: (2019)

Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition
por: Jin, H-O, et al.
Publicado: (2012)

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
por: Wu, Tao, et al.
Publicado: (2015)

mTOR Signaling and Potential Therapeutic Targeting in Meningioma
por: Pinker, Benjamin, et al.
Publicado: (2022)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury
por: Xiao, Zhipeng, et al.
Publicado: (2019)

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
por: Shi, W-Y, et al.
Publicado: (2012)

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
por: You, Ganhua, et al.
Publicado: (2020)

Metformin enhances the chemosensitivity of hepatocarcinoma cells to cisplatin through AMPK pathway
por: Dong, Hao, et al.
Publicado: (2017)

Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway
por: Wu, Hongqiang, et al.
Publicado: (2019)

Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy
por: Qiu, Xiaobo, et al.
Publicado: (2021)

Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro
por: Fan, Yuying, et al.
Publicado: (2021)

Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells
por: Yang, Huahong, et al.
Publicado: (2019)

Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling
por: Lu, Chi-Cheng, et al.
Publicado: (2019)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling
por: Zhao, Ting, et al.
Publicado: (2021)

Mannan-BAM, TLR Ligands, Anti-CD40 Antibody (MBTA) Vaccine Immunotherapy: A Review of Current Evidence and Applications in Glioblastoma
por: Lookian, Pashayar P., et al.
Publicado: (2021)

Full title: High glucose protects mesenchymal stem cells from metformin-induced apoptosis through the AMPK-mediated mTOR pathway
por: He, Xiao, et al.
Publicado: (2019)

Metformin prevents PFKFB3-related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway
por: Tang, Ci-Jun, et al.
Publicado: (2021)

Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma
por: Cui, Jing, et al.
Publicado: (2020)

Overcoming cisplatin resistance by mTOR inhibitor in lung cancer
por: Wu, Chunjing, et al.
Publicado: (2005)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways
por: Morelli, Ana Paula, et al.
Publicado: (2021)

SPAG6 silencing induces autophagic cell death in SKM-1 cells via the AMPK/mTOR/ULK1 signaling pathway
por: Zhang, Meng, et al.
Publicado: (2020)

Metformin induces degradation of mTOR protein in breast cancer cells
por: Alalem, Mohamed, et al.
Publicado: (2016)

Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis
por: Su, Shuai, et al.
Publicado: (2021)

Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro
por: He, Caigu, et al.
Publicado: (2020)

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens
por: Brunton, Jason, et al.
Publicado: (2013)

Retraction: Central Exercise Action Increases the AMPK and mTOR Response to Leptin
Publicado: (2018)

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
por: Su, Yuan, et al.
Publicado: (2019)

Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
por: Xu, Shengyu, et al.
Publicado: (2020)

How does mTOR sense glucose starvation? AMPK is the usual suspect
por: Leprivier, Gabriel, et al.
Publicado: (2020)

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
por: Ramirez Reyes, Josué M. J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i8crjvn422c1tccql9l899kla1