Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

Osteosarcoma is the most frequent and aggressive bone tumor in children and adolescents, with a long-term survival rate of 30%. Interleukin-12 (IL-12) is a potent cytokine that bridges innate and adaptive immunity, triggers antiangiogenic responses, and achieves potent antitumor effects. In this wor...

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Detalles Bibliográficos
Autores principales: Zalacain, Marta, Bunuales, María, Marrodan, Lucía, Labiano, Sara, Gonzalez-Huarriz, Marisol, Martinez-Vélez, Naiara, Laspidea, Virginia, Puigdelloses, Montse, García-Moure, Marc, Gonzalez-Aparicio, Manuela, Hernandez-Alcoceba, Rubén, Alonso, Marta M., Patiño-García, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851487/
https://www.ncbi.nlm.nih.gov/pubmed/33575468
http://dx.doi.org/10.1016/j.omto.2020.11.003

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