Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance

Oncolytic virotherapy (OVT) has been suggested to be effective. However, the suppressive effects of checkpoints and insufficient costimulatory signals limit OVT-induced antitumor immune responses. In this study, we constructed a replicative adenovirus, Ad5sPVR, that expresses the soluble extracellul...

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Detalles Bibliográficos
Autores principales: Zhang, Hailin, Zhang, Yonghui, Dong, Jie, Li, Binghua, Xu, Chun, Wei, Min, Wu, Junhua, Wei, Jiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851489/
https://www.ncbi.nlm.nih.gov/pubmed/33575467
http://dx.doi.org/10.1016/j.omto.2020.11.001

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