Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche

Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of cancer. However, there is conflicting evidence about w...

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Detalles Bibliográficos
Autores principales: Yasuda, Tadahito, Ishimoto, Takatsugu, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851492/
https://www.ncbi.nlm.nih.gov/pubmed/33598509
http://dx.doi.org/10.1016/j.reth.2021.01.005
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author Yasuda, Tadahito
Ishimoto, Takatsugu
Baba, Hideo
author_facet Yasuda, Tadahito
Ishimoto, Takatsugu
Baba, Hideo
author_sort Yasuda, Tadahito
collection PubMed
description Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of cancer. However, there is conflicting evidence about whether CSCs depend on glycolysis or mitochondrial oxidative phosphorylation (OXPHOS) to maintain their stem cell properties. This review summarizes the latest knowledge regarding CSC-specific metabolic alterations and offers recent evidence that the surrounding microenvironments may play an important role in the maintenance of CSC properties.
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spelling pubmed-78514922021-02-16 Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche Yasuda, Tadahito Ishimoto, Takatsugu Baba, Hideo Regen Ther Original Article Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of cancer. However, there is conflicting evidence about whether CSCs depend on glycolysis or mitochondrial oxidative phosphorylation (OXPHOS) to maintain their stem cell properties. This review summarizes the latest knowledge regarding CSC-specific metabolic alterations and offers recent evidence that the surrounding microenvironments may play an important role in the maintenance of CSC properties. Japanese Society for Regenerative Medicine 2021-01-29 /pmc/articles/PMC7851492/ /pubmed/33598509 http://dx.doi.org/10.1016/j.reth.2021.01.005 Text en © 2021 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Yasuda, Tadahito
Ishimoto, Takatsugu
Baba, Hideo
Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title_full Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title_fullStr Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title_full_unstemmed Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title_short Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
title_sort conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851492/
https://www.ncbi.nlm.nih.gov/pubmed/33598509
http://dx.doi.org/10.1016/j.reth.2021.01.005
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