Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma

Glioblastoma is an invariably deadly disease. A subpopulation of glioma stem-like cells (GSCs) drives tumor progression and treatment resistance. Two recent studies demonstrated that neurons form oncogenic glutamatergic electrochemical synapses with post-synaptic GSCs. This led us to explore whether...

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Detalles Bibliográficos
Autores principales: Wirsching, Hans-Georg, Silginer, Manuela, Ventura, Elisa, Macnair, Will, Burghardt, Isabel, Claassen, Manfred, Gatti, Silvia, Wichmann, Jürgen, Riemer, Claus, Schneider, Hannah, Weller, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851500/
https://www.ncbi.nlm.nih.gov/pubmed/33575479
http://dx.doi.org/10.1016/j.omto.2020.12.009

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