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A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

Despite therapeutic advances, the effective treatment for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) remains a major clinical challenge. Evasion of apoptosis through upregulating antiapoptotic B-cell lymphoma-2 (BCL-2) family members and p53 inactivation, and abnormal activation of...

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Detalles Bibliográficos
Autores principales:	Luo, Qiuyun, Pan, Wentao, Zhou, Suna, Wang, Guangfeng, Yi, Hanjie, Zhang, Lin, Yan, Xianglei, Yuan, Luping, Liu, Zhenyi, Wang, Jing, Chen, Haibo, Qiu, MiaoZhen, Yang, DaJun, Sun, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851508/ https://www.ncbi.nlm.nih.gov/pubmed/32093809 http://dx.doi.org/10.3727/096504020X15825405463920

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