Cargando…
Comparative Genomics within and across Bilaterians Illuminates the Evolutionary History of ALK and LTK Proto-Oncogene Origination and Diversification
Comparative genomic analyses have enormous potential for identifying key genes central to human health phenotypes, including those that promote cancers. In particular, the successful development of novel therapeutics using model species requires phylogenetic analyses to determine molecular homology....
Autores principales: | Dornburg, Alex, Wang, Zheng, Wang, Junrui, Mo, Elizabeth S, López-Giráldez, Francesc, Townsend, Jeffrey P |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851593/ https://www.ncbi.nlm.nih.gov/pubmed/33196781 http://dx.doi.org/10.1093/gbe/evaa228 |
Ejemplares similares
-
ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation
por: Roll, J. Devon, et al.
Publicado: (2012) -
The evolutionary origin of bilaterian smooth and striated myocytes
por: Brunet, Thibaut, et al.
Publicado: (2016) -
Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480
por: Gudernova, Iva, et al.
Publicado: (2017) -
LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity
por: Christova, Tania, et al.
Publicado: (2023) -
LTK is an ER-resident receptor tyrosine kinase that regulates secretion
por: Centonze, Federica G., et al.
Publicado: (2019)