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Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)
The negative symptoms of schizophrenia are an unmet treatment target as currently approved treatments mostly control positive symptoms. The persistence of these symptoms holds back the patient's reinstatement in society, making them incapable of fulfilling their social, professional, or family...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851661/ https://www.ncbi.nlm.nih.gov/pubmed/33603883 http://dx.doi.org/10.3892/etm.2021.9707 |
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author | Căpățînă, Octavia O. Micluția, Ioana V. Fadgyas-Stănculete, Mihaela |
author_facet | Căpățînă, Octavia O. Micluția, Ioana V. Fadgyas-Stănculete, Mihaela |
author_sort | Căpățînă, Octavia O. |
collection | PubMed |
description | The negative symptoms of schizophrenia are an unmet treatment target as currently approved treatments mostly control positive symptoms. The persistence of these symptoms holds back the patient's reinstatement in society, making them incapable of fulfilling their social, professional, or family roles. There is overwhelming research evidence suggesting that the negative symptoms of schizophrenia are associated with poorer functioning and lower quality of life than positive symptoms, confirming the need for developing new treatments for this particular category of symptoms. This present review aims to review clinical trials addressing novel pharmacological approaches addressing primary negative symptoms of schizophrenia. We overview both monotherapies, first-generation and second-generation antipsychotics, and add-on therapies, including psychostimulants, anti-inflammatory drugs, antidepressants, molecules targeting glutamatergic, cholinergic or serotonergic systems and hormones. Our findings suggest that the primary negative symptoms of schizophrenia may be mitigated by adjunctive therapies, and we highlight the pharmacological agents that have proven superior efficacy. Novel compounds such as cariprazine and MIN-101, to date, show promising results, but large clinical trials are needed to test their efficacy and safety. |
format | Online Article Text |
id | pubmed-7851661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-78516612021-02-17 Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) Căpățînă, Octavia O. Micluția, Ioana V. Fadgyas-Stănculete, Mihaela Exp Ther Med Review The negative symptoms of schizophrenia are an unmet treatment target as currently approved treatments mostly control positive symptoms. The persistence of these symptoms holds back the patient's reinstatement in society, making them incapable of fulfilling their social, professional, or family roles. There is overwhelming research evidence suggesting that the negative symptoms of schizophrenia are associated with poorer functioning and lower quality of life than positive symptoms, confirming the need for developing new treatments for this particular category of symptoms. This present review aims to review clinical trials addressing novel pharmacological approaches addressing primary negative symptoms of schizophrenia. We overview both monotherapies, first-generation and second-generation antipsychotics, and add-on therapies, including psychostimulants, anti-inflammatory drugs, antidepressants, molecules targeting glutamatergic, cholinergic or serotonergic systems and hormones. Our findings suggest that the primary negative symptoms of schizophrenia may be mitigated by adjunctive therapies, and we highlight the pharmacological agents that have proven superior efficacy. Novel compounds such as cariprazine and MIN-101, to date, show promising results, but large clinical trials are needed to test their efficacy and safety. D.A. Spandidos 2021-03 2021-01-25 /pmc/articles/PMC7851661/ /pubmed/33603883 http://dx.doi.org/10.3892/etm.2021.9707 Text en Copyright: © Căpățînă et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Căpățînă, Octavia O. Micluția, Ioana V. Fadgyas-Stănculete, Mihaela Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title | Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title_full | Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title_fullStr | Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title_full_unstemmed | Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title_short | Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review) |
title_sort | current perspectives in treating negative symptoms of schizophrenia: a narrative review (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851661/ https://www.ncbi.nlm.nih.gov/pubmed/33603883 http://dx.doi.org/10.3892/etm.2021.9707 |
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