TNF-α Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-α Production and Enhancing T Cell Activation

Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. They can produce massive amounts of type I IFNs in response to nucleic acids via TLRs, but they are also known to possess weak Ag-presenting properties inducing CD4(+) T cell activation. Previous studies show...

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Detalles Bibliográficos
Autores principales: Psarras, Antonios, Antanaviciute, Agne, Alase, Adewonuola, Carr, Ian, Wittmann, Miriam, Emery, Paul, Tsokos, George C., Vital, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2021
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851743/
https://www.ncbi.nlm.nih.gov/pubmed/33441439
http://dx.doi.org/10.4049/jimmunol.1901358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851743/
https://www.ncbi.nlm.nih.gov/pubmed/33441439
http://dx.doi.org/10.4049/jimmunol.1901358

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