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Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial

BACKGROUND: Epidemiological studies have reported lower risk of cardiovascular disease with moderate coffee consumption. In addition, emerging evidence indicates that consumption of coffee beverages enriched in chlorogenic acids (CGAs) may influence blood pressure and endothelial function, suggestin...

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Autores principales: Naylor, Louise H, Zimmermann, Diane, Guitard-Uldry, Marjorie, Poquet, Laure, Lévêques, Antoine, Eriksen, Bjorn, Bel Rhlid, Rachid, Galaffu, Nicola, D'Urzo, Carmine, De Castro, Antonio, Van Schaick, Erno, Green, Daniel J, Actis-Goretta, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851825/
https://www.ncbi.nlm.nih.gov/pubmed/33330899
http://dx.doi.org/10.1093/ajcn/nqaa312
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author Naylor, Louise H
Zimmermann, Diane
Guitard-Uldry, Marjorie
Poquet, Laure
Lévêques, Antoine
Eriksen, Bjorn
Bel Rhlid, Rachid
Galaffu, Nicola
D'Urzo, Carmine
De Castro, Antonio
Van Schaick, Erno
Green, Daniel J
Actis-Goretta, Lucas
author_facet Naylor, Louise H
Zimmermann, Diane
Guitard-Uldry, Marjorie
Poquet, Laure
Lévêques, Antoine
Eriksen, Bjorn
Bel Rhlid, Rachid
Galaffu, Nicola
D'Urzo, Carmine
De Castro, Antonio
Van Schaick, Erno
Green, Daniel J
Actis-Goretta, Lucas
author_sort Naylor, Louise H
collection PubMed
description BACKGROUND: Epidemiological studies have reported lower risk of cardiovascular disease with moderate coffee consumption. In addition, emerging evidence indicates that consumption of coffee beverages enriched in chlorogenic acids (CGAs) may influence blood pressure and endothelial function, suggesting that the beneficial cardiovascular effect of coffee may relate to its CGA content. OBJECTIVES: We conducted a double-blind randomized crossover trial to test the effect of acute consumption of a decaffeinated green coffee extract (DGCE), rich in CGAs, on endothelial function in healthy subjects. METHODS: We compared 3 different doses of DGCE (302, 604, and 906 mg, respectively) with a placebo. Endothelial function was defined as the percentage change in the internal diameter of the brachial artery in response to flow-mediated dilation (%FMD). In addition, we followed the plasma concentration-time profiles of 25 systemic CGA metabolites over 24 h after DGCE consumption and we explored the relation between systemic concentrations of CGAs and the effect on %FMD. RESULTS: The DGCE formulations containing different amounts of CGAs resulted in dose-proportional increases in overall total polyphenol concentrations. The systemic appearance of total CGAs was biphasic, in agreement with previous results suggesting 2 sites of absorption in the gastrointestinal tract. Compared with the placebo group, a significant FMD increase (>1%) was observed 8.5, 10, and 24 h after consumption of 302 mg DGCE (∼156.4 mg CGAs). The differences with placebo observed in the other 2 groups were not statistically significant. Evaluation of the relation between phenolic exposure and %FMD showed a positive tendency toward a larger effect at higher concentrations and different behavior of CGA metabolites depending on the conjugated chemical position. CONCLUSIONS: We demonstrated an acute improvement in %FMD over time after ingestion of a DGCE, explained at least partly by the presence in the blood circulation of CGAs and their metabolites. This trial was registered at clinicaltrials.gov as NCT03520452.
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spelling pubmed-78518252021-02-04 Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial Naylor, Louise H Zimmermann, Diane Guitard-Uldry, Marjorie Poquet, Laure Lévêques, Antoine Eriksen, Bjorn Bel Rhlid, Rachid Galaffu, Nicola D'Urzo, Carmine De Castro, Antonio Van Schaick, Erno Green, Daniel J Actis-Goretta, Lucas Am J Clin Nutr Original Research Communications BACKGROUND: Epidemiological studies have reported lower risk of cardiovascular disease with moderate coffee consumption. In addition, emerging evidence indicates that consumption of coffee beverages enriched in chlorogenic acids (CGAs) may influence blood pressure and endothelial function, suggesting that the beneficial cardiovascular effect of coffee may relate to its CGA content. OBJECTIVES: We conducted a double-blind randomized crossover trial to test the effect of acute consumption of a decaffeinated green coffee extract (DGCE), rich in CGAs, on endothelial function in healthy subjects. METHODS: We compared 3 different doses of DGCE (302, 604, and 906 mg, respectively) with a placebo. Endothelial function was defined as the percentage change in the internal diameter of the brachial artery in response to flow-mediated dilation (%FMD). In addition, we followed the plasma concentration-time profiles of 25 systemic CGA metabolites over 24 h after DGCE consumption and we explored the relation between systemic concentrations of CGAs and the effect on %FMD. RESULTS: The DGCE formulations containing different amounts of CGAs resulted in dose-proportional increases in overall total polyphenol concentrations. The systemic appearance of total CGAs was biphasic, in agreement with previous results suggesting 2 sites of absorption in the gastrointestinal tract. Compared with the placebo group, a significant FMD increase (>1%) was observed 8.5, 10, and 24 h after consumption of 302 mg DGCE (∼156.4 mg CGAs). The differences with placebo observed in the other 2 groups were not statistically significant. Evaluation of the relation between phenolic exposure and %FMD showed a positive tendency toward a larger effect at higher concentrations and different behavior of CGA metabolites depending on the conjugated chemical position. CONCLUSIONS: We demonstrated an acute improvement in %FMD over time after ingestion of a DGCE, explained at least partly by the presence in the blood circulation of CGAs and their metabolites. This trial was registered at clinicaltrials.gov as NCT03520452. Oxford University Press 2020-12-16 /pmc/articles/PMC7851825/ /pubmed/33330899 http://dx.doi.org/10.1093/ajcn/nqaa312 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Research Communications
Naylor, Louise H
Zimmermann, Diane
Guitard-Uldry, Marjorie
Poquet, Laure
Lévêques, Antoine
Eriksen, Bjorn
Bel Rhlid, Rachid
Galaffu, Nicola
D'Urzo, Carmine
De Castro, Antonio
Van Schaick, Erno
Green, Daniel J
Actis-Goretta, Lucas
Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title_full Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title_fullStr Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title_full_unstemmed Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title_short Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
title_sort acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial
topic Original Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851825/
https://www.ncbi.nlm.nih.gov/pubmed/33330899
http://dx.doi.org/10.1093/ajcn/nqaa312
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