Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

Telomere maintenance is essential for the long-term proliferation of human pluripotent stem cells, while their telomere length set point determines the proliferative capacity of their differentiated progeny. The shelterin protein TPP1 is required for telomere stability and elongation, but its role i...

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Detalles Bibliográficos
Autores principales: Boyle, John M., Hennick, Kelsey M., Regalado, Samuel G., Vogan, Jacob M., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851873/
https://www.ncbi.nlm.nih.gov/pubmed/32903138
http://dx.doi.org/10.1091/mbc.E19-08-0447

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