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Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan
BACKGROUND: We hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD. METHODS: A total of 657 patients registered in the Yokohama City University...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851921/ https://www.ncbi.nlm.nih.gov/pubmed/33522943 http://dx.doi.org/10.1186/s13075-020-02406-6 |
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author | Soejima, Yutaro Kirino, Yohei Takeno, Mitsuhiro Kurosawa, Michiko Takeuchi, Masaki Yoshimi, Ryusuke Sugiyama, Yumiko Ohno, Shigeru Asami, Yukiko Sekiguchi, Akiko Igarashi, Toshihisa Nagaoka, Shohei Ishigatsubo, Yoshiaki Nakajima, Hideaki Mizuki, Nobuhisa |
author_facet | Soejima, Yutaro Kirino, Yohei Takeno, Mitsuhiro Kurosawa, Michiko Takeuchi, Masaki Yoshimi, Ryusuke Sugiyama, Yumiko Ohno, Shigeru Asami, Yukiko Sekiguchi, Akiko Igarashi, Toshihisa Nagaoka, Shohei Ishigatsubo, Yoshiaki Nakajima, Hideaki Mizuki, Nobuhisa |
author_sort | Soejima, Yutaro |
collection | PubMed |
description | BACKGROUND: We hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD. METHODS: A total of 657 patients registered in the Yokohama City University (YCU) regional BD registry between 1990 and 2018, as well as 6754 patients who were initially registered in the Japanese Ministry of Health, Labour and Welfare (MHLW) database between 2003 and 2014, were investigated. The YCU registry data regarding the clinical manifestations of BD, human leukocyte antigen (HLA) status, treatments, and hospitalizations were analyzed first, followed by similar analyses of the MHLW for validation. A hierarchical cluster analysis was independently performed in both patient groups. RESULTS: A hierarchical cluster analysis determined five independent clinical clusters in the YCU cohort. Individual counterparts of the YCU clusters were confirmed in the MHLW registry. Recent phenotypical evolutions of BD in Japan, such as increased gastrointestinal (GI) involvement, reduced complete type according to the Japan Criteria, and reduced HLA-B51 positivity were associated with chronologically changing proportions of the clinical clusters. CONCLUSIONS: In this study, we identified independent clinical clusters among BD patients in Japan and found that the proportion of each cluster varied over time. We propose five independent clusters namely “mucocutaneous”, “mucocutaneous with arthritis”, “neuro”, “GI”, and “eye.” |
format | Online Article Text |
id | pubmed-7851921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78519212021-02-03 Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan Soejima, Yutaro Kirino, Yohei Takeno, Mitsuhiro Kurosawa, Michiko Takeuchi, Masaki Yoshimi, Ryusuke Sugiyama, Yumiko Ohno, Shigeru Asami, Yukiko Sekiguchi, Akiko Igarashi, Toshihisa Nagaoka, Shohei Ishigatsubo, Yoshiaki Nakajima, Hideaki Mizuki, Nobuhisa Arthritis Res Ther Research Article BACKGROUND: We hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD. METHODS: A total of 657 patients registered in the Yokohama City University (YCU) regional BD registry between 1990 and 2018, as well as 6754 patients who were initially registered in the Japanese Ministry of Health, Labour and Welfare (MHLW) database between 2003 and 2014, were investigated. The YCU registry data regarding the clinical manifestations of BD, human leukocyte antigen (HLA) status, treatments, and hospitalizations were analyzed first, followed by similar analyses of the MHLW for validation. A hierarchical cluster analysis was independently performed in both patient groups. RESULTS: A hierarchical cluster analysis determined five independent clinical clusters in the YCU cohort. Individual counterparts of the YCU clusters were confirmed in the MHLW registry. Recent phenotypical evolutions of BD in Japan, such as increased gastrointestinal (GI) involvement, reduced complete type according to the Japan Criteria, and reduced HLA-B51 positivity were associated with chronologically changing proportions of the clinical clusters. CONCLUSIONS: In this study, we identified independent clinical clusters among BD patients in Japan and found that the proportion of each cluster varied over time. We propose five independent clusters namely “mucocutaneous”, “mucocutaneous with arthritis”, “neuro”, “GI”, and “eye.” BioMed Central 2021-02-01 2021 /pmc/articles/PMC7851921/ /pubmed/33522943 http://dx.doi.org/10.1186/s13075-020-02406-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Soejima, Yutaro Kirino, Yohei Takeno, Mitsuhiro Kurosawa, Michiko Takeuchi, Masaki Yoshimi, Ryusuke Sugiyama, Yumiko Ohno, Shigeru Asami, Yukiko Sekiguchi, Akiko Igarashi, Toshihisa Nagaoka, Shohei Ishigatsubo, Yoshiaki Nakajima, Hideaki Mizuki, Nobuhisa Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title | Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title_full | Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title_fullStr | Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title_full_unstemmed | Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title_short | Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet’s disease in Japan |
title_sort | changes in the proportion of clinical clusters contribute to the phenotypic evolution of behçet’s disease in japan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851921/ https://www.ncbi.nlm.nih.gov/pubmed/33522943 http://dx.doi.org/10.1186/s13075-020-02406-6 |
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