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Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BACKGROUND: Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential. During aging, heterogeneity of HSCs changes, contributing to the deterioration of the immune system. In this study, we revisited mouse HSC compartm...

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Detalles Bibliográficos
Autores principales:	Hérault, Léonard, Poplineau, Mathilde, Mazuel, Adrien, Platet, Nadine, Remy, Élisabeth, Duprez, Estelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851934/ https://www.ncbi.nlm.nih.gov/pubmed/33526011 http://dx.doi.org/10.1186/s12915-021-00955-z

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