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A single nucleotide mutation drastically increases the expression of tumor-homing NGR-TNFα in the E. coli M15-pQE30 system by improving gene transcription

ABSTRACT: Due to their potent immune stimulation, tumor necrosis factor alpha (TNFα) variants with tumor-homing activity are attractive as novel antitumor drugs. The promising antitumor effect of NGR-TNFα in clinical trials triggered extensive interest in developing novel tumor-homing TNFα variants...

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Detalles Bibliográficos
Autores principales:	Chen, Jie, Yang, Hao, Feng, Yanru, Shi, Qiuxiao, Li, Zhao, Tao, Ze, Fan, Jie, Jin, Youmei, Li, Shengfu, Cheng, Jingqiu, Lu, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Biotechnological Products and Process Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852052/ https://www.ncbi.nlm.nih.gov/pubmed/33528691 http://dx.doi.org/10.1007/s00253-021-11136-x

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