Multiplexed single‐cell mass cytometry reveals distinct inhibitory effects on intracellular phosphoproteins by midostaurin in combination with chemotherapy in AML cells

BACKGROUND: Fms-related tyrosine kinase 3 (FLT3) receptor serves as a prognostic marker and therapeutic target in acute myeloid leukemia (AML). Approximately one-third of AML patients carry mutation in FLT3, associated with unfavourable prognosis and high relapse rate. The multitargeted kinase inhib...

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Detalles Bibliográficos
Autores principales: Rörby, Emma, Adolfsson, Jörgen, Hultin, Erik, Gustafsson, Thomas, Lotfi, Kourosh, Cammenga, Jörg, Jönsson, Jan-Ingvar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852110/
https://www.ncbi.nlm.nih.gov/pubmed/33531064
http://dx.doi.org/10.1186/s40164-021-00201-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852110/
https://www.ncbi.nlm.nih.gov/pubmed/33531064
http://dx.doi.org/10.1186/s40164-021-00201-w

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