Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes

Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiat...

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Autores principales: Tanosaki, Sho, Tohyama, Shugo, Kishino, Yoshikazu, Fujita, Jun, Fukuda, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852150/
https://www.ncbi.nlm.nih.gov/pubmed/33526069
http://dx.doi.org/10.1186/s41232-021-00156-9
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author Tanosaki, Sho
Tohyama, Shugo
Kishino, Yoshikazu
Fujita, Jun
Fukuda, Keiichi
author_facet Tanosaki, Sho
Tohyama, Shugo
Kishino, Yoshikazu
Fujita, Jun
Fukuda, Keiichi
author_sort Tanosaki, Sho
collection PubMed
description Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
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spelling pubmed-78521502021-02-09 Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes Tanosaki, Sho Tohyama, Shugo Kishino, Yoshikazu Fujita, Jun Fukuda, Keiichi Inflamm Regen Review Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy. BioMed Central 2021-02-01 /pmc/articles/PMC7852150/ /pubmed/33526069 http://dx.doi.org/10.1186/s41232-021-00156-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Tanosaki, Sho
Tohyama, Shugo
Kishino, Yoshikazu
Fujita, Jun
Fukuda, Keiichi
Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title_full Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title_fullStr Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title_full_unstemmed Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title_short Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
title_sort metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852150/
https://www.ncbi.nlm.nih.gov/pubmed/33526069
http://dx.doi.org/10.1186/s41232-021-00156-9
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