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More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis

COVID-19, caused by SARS-CoV-2, can involve sequelae and other medical complications that last weeks to months after initial recovery, which has come to be called Long-COVID or COVID long-haulers. This systematic review and meta-analysis aims to identify studies assessing long-term effects of COVID-...

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Autores principales: Lopez-Leon, Sandra, Wegman-Ostrosky, Talia, Perelman, Carol, Sepulveda, Rosalinda, Rebolledo, Paulina A, Cuapio, Angelica, Villapol, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852236/
https://www.ncbi.nlm.nih.gov/pubmed/33532785
http://dx.doi.org/10.1101/2021.01.27.21250617
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author Lopez-Leon, Sandra
Wegman-Ostrosky, Talia
Perelman, Carol
Sepulveda, Rosalinda
Rebolledo, Paulina A
Cuapio, Angelica
Villapol, Sonia
author_facet Lopez-Leon, Sandra
Wegman-Ostrosky, Talia
Perelman, Carol
Sepulveda, Rosalinda
Rebolledo, Paulina A
Cuapio, Angelica
Villapol, Sonia
author_sort Lopez-Leon, Sandra
collection PubMed
description COVID-19, caused by SARS-CoV-2, can involve sequelae and other medical complications that last weeks to months after initial recovery, which has come to be called Long-COVID or COVID long-haulers. This systematic review and meta-analysis aims to identify studies assessing long-term effects of COVID-19 and estimates the prevalence of each symptom, sign, or laboratory parameter of patients at a post-COVID-19 stage. LitCOVID (PubMed and Medline) and Embase were searched by two independent researchers. All articles with original data for detecting long-term COVID-19 published before 1(st) of January 2021 and with a minimum of 100 patients were included. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. Heterogeneity was assessed using I(2) statistics. This systematic review followed Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) guidelines, although the study protocol was not registered. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included. The follow-up time ranged from 14 to 110 days post-viral infection. The age of the study participants ranged between 17 and 87 years. It was estimated that 80% (95% CI 65–92) of the patients that were infected with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). All meta-analyses showed medium (n=2) to high heterogeneity (n=13). In order to have a better understanding, future studies need to stratify by sex, age, previous comorbidities, severity of COVID-19 (ranging from asymptomatic to severe), and duration of each symptom. From the clinical perspective, multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.
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spelling pubmed-78522362021-02-03 More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis Lopez-Leon, Sandra Wegman-Ostrosky, Talia Perelman, Carol Sepulveda, Rosalinda Rebolledo, Paulina A Cuapio, Angelica Villapol, Sonia medRxiv Article COVID-19, caused by SARS-CoV-2, can involve sequelae and other medical complications that last weeks to months after initial recovery, which has come to be called Long-COVID or COVID long-haulers. This systematic review and meta-analysis aims to identify studies assessing long-term effects of COVID-19 and estimates the prevalence of each symptom, sign, or laboratory parameter of patients at a post-COVID-19 stage. LitCOVID (PubMed and Medline) and Embase were searched by two independent researchers. All articles with original data for detecting long-term COVID-19 published before 1(st) of January 2021 and with a minimum of 100 patients were included. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. Heterogeneity was assessed using I(2) statistics. This systematic review followed Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) guidelines, although the study protocol was not registered. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included. The follow-up time ranged from 14 to 110 days post-viral infection. The age of the study participants ranged between 17 and 87 years. It was estimated that 80% (95% CI 65–92) of the patients that were infected with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). All meta-analyses showed medium (n=2) to high heterogeneity (n=13). In order to have a better understanding, future studies need to stratify by sex, age, previous comorbidities, severity of COVID-19 (ranging from asymptomatic to severe), and duration of each symptom. From the clinical perspective, multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care. Cold Spring Harbor Laboratory 2021-01-30 /pmc/articles/PMC7852236/ /pubmed/33532785 http://dx.doi.org/10.1101/2021.01.27.21250617 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Lopez-Leon, Sandra
Wegman-Ostrosky, Talia
Perelman, Carol
Sepulveda, Rosalinda
Rebolledo, Paulina A
Cuapio, Angelica
Villapol, Sonia
More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title_full More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title_fullStr More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title_full_unstemmed More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title_short More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
title_sort more than 50 long-term effects of covid-19: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852236/
https://www.ncbi.nlm.nih.gov/pubmed/33532785
http://dx.doi.org/10.1101/2021.01.27.21250617
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