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Effect of mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell-cell fusion function

The SARS-CoV-2 spike protein (S) is the sole viral protein responsible for both viral binding to a host cell and the membrane fusion event needed for cell entry. In addition to facilitating fusion needed for viral entry, S can also drive cell-cell fusion, a pathogenic effect observed in the lungs of...

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Detalles Bibliográficos
Autores principales:	Barrett, Chelsea T., Neal, Hadley E., Edmonds, Kearstin, Moncman, Carole L., Thompson, Rachel, Branttie, Jean M., Boggs, Kerri Beth, Wu, Cheng-Yu, Leung, Daisy W., Dutch, Rebecca E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852270/ https://www.ncbi.nlm.nih.gov/pubmed/33532777 http://dx.doi.org/10.1101/2021.01.24.428007

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