Osteoblasts mineralization and collagen matrix are conserved upon specific Col1a2 silencing

Classical osteogenesis imperfecta (OI) is an inherited rare brittle bone disease caused by dominant mutations in the COL1A1 or COL1A2 genes, encoding for the α chains of collagen type I. The definitive cure for the disease will require a gene therapy approach, aimed to correct or suppress the mutant...

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Detalles Bibliográficos
Autores principales: Maruelli, Silvia, Besio, Roberta, Rousseau, Julie, Garibaldi, Nadia, Amiaud, Jérôme, Brulin, Bénédicte, Layrolle, Pierre, Escriou, Virginie, Rossi, Antonio, Trichet, Valerie, Forlino, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852305/
https://www.ncbi.nlm.nih.gov/pubmed/33543025
http://dx.doi.org/10.1016/j.mbplus.2020.100028

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