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Collagen XV, a multifaceted multiplexin present across tissues and species

Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic prop...

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Autores principales: Bretaud, Sandrine, Guillon, Emilie, Karppinen, Sanna-Maria, Pihlajaniemi, Taina, Ruggiero, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852327/
https://www.ncbi.nlm.nih.gov/pubmed/33543021
http://dx.doi.org/10.1016/j.mbplus.2020.100023
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author Bretaud, Sandrine
Guillon, Emilie
Karppinen, Sanna-Maria
Pihlajaniemi, Taina
Ruggiero, Florence
author_facet Bretaud, Sandrine
Guillon, Emilie
Karppinen, Sanna-Maria
Pihlajaniemi, Taina
Ruggiero, Florence
author_sort Bretaud, Sandrine
collection PubMed
description Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic properties were subjects of wide interest in the past years. But during the last fifteen years, collagen XV has gained growing attention with increasing number of studies that have attributed new functions to this widely distributed collagen/proteoglycan hybrid molecule. Despite the cumulative evidence of its functional pleiotropy and its evolutionary conserved function, no review compiling the current state of the art about collagen XV is currently available. Here, we thus provide the first comprehensive view of the knowledge gathered so far on the molecular structure, tissue distribution and functions of collagen XV in development, tissue homeostasis and disease with an evolutionary perspective. We hope that our review will open new roads for promising research on collagen XV in the coming years.
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spelling pubmed-78523272021-02-03 Collagen XV, a multifaceted multiplexin present across tissues and species Bretaud, Sandrine Guillon, Emilie Karppinen, Sanna-Maria Pihlajaniemi, Taina Ruggiero, Florence Matrix Biol Plus Article Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostatin whose anti-angiogenic and anti-tumorigenic properties were subjects of wide interest in the past years. But during the last fifteen years, collagen XV has gained growing attention with increasing number of studies that have attributed new functions to this widely distributed collagen/proteoglycan hybrid molecule. Despite the cumulative evidence of its functional pleiotropy and its evolutionary conserved function, no review compiling the current state of the art about collagen XV is currently available. Here, we thus provide the first comprehensive view of the knowledge gathered so far on the molecular structure, tissue distribution and functions of collagen XV in development, tissue homeostasis and disease with an evolutionary perspective. We hope that our review will open new roads for promising research on collagen XV in the coming years. Elsevier 2020-01-15 /pmc/articles/PMC7852327/ /pubmed/33543021 http://dx.doi.org/10.1016/j.mbplus.2020.100023 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bretaud, Sandrine
Guillon, Emilie
Karppinen, Sanna-Maria
Pihlajaniemi, Taina
Ruggiero, Florence
Collagen XV, a multifaceted multiplexin present across tissues and species
title Collagen XV, a multifaceted multiplexin present across tissues and species
title_full Collagen XV, a multifaceted multiplexin present across tissues and species
title_fullStr Collagen XV, a multifaceted multiplexin present across tissues and species
title_full_unstemmed Collagen XV, a multifaceted multiplexin present across tissues and species
title_short Collagen XV, a multifaceted multiplexin present across tissues and species
title_sort collagen xv, a multifaceted multiplexin present across tissues and species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852327/
https://www.ncbi.nlm.nih.gov/pubmed/33543021
http://dx.doi.org/10.1016/j.mbplus.2020.100023
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